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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by creepy on January 20, 2021, at 15:01:02
I just got done doing an emsam trial after failing phenelzine a couple months ago due to high blood sugar / blood pressure.
For you people that are on parnate, do you get the feeling that there is something in the medication itself that has AD properties or is it only the MAO effect? I just worry since its half-life is so short compared to the other MAOIs
I can tell there is an inherent AD effect in selegiline on top of the MAO effect I get from taking it till my MAO levels drop enough to exhibit symptoms like lowered BP. At 9mg it isnt enough for a full remission but im certainly better off than before. Doctor doesnt seem to want to do 12mg I may insist on a trial of it first though. Washout sucks.
Posted by undopaminergic on January 22, 2021, at 3:16:24
In reply to parnate, posted by creepy on January 20, 2021, at 15:01:02
> I just got done doing an emsam trial after failing phenelzine a couple months ago due to high blood sugar / blood pressure.
> For you people that are on parnate, do you get the feeling that there is something in the medication itself that has AD properties or is it only the MAO effect? I just worry since its half-life is so short compared to the other MAOIs
> I can tell there is an inherent AD effect in selegiline on top of the MAO effect I get from taking it till my MAO levels drop enough to exhibit symptoms like lowered BP. At 9mg it isnt enough for a full remission but im certainly better off than before. Doctor doesnt seem to want to do 12mg I may insist on a trial of it first though. Washout sucks.
>Tranylcypromine (Parnate) does have effects beyond MAO inhibition. It is an amphetamine-like stimulant.
You don't need a washout if you're going from one MAOI to another.
-undopaminergic
Posted by creepy on January 24, 2021, at 18:31:16
In reply to Re: parnate, posted by undopaminergic on January 22, 2021, at 3:16:24
I agree about the washout. But the doctors at this clinic are really ignorant of a lot of pharmacology, especially MAOI it took me a huge effort to even get emsam prescribed.
Selegiline has stimulant qualities too for a short while then after that its kind of sleepy actually.
Does parnate remain stimulating? Im guessing the sedation is a quality of all MAOI via melatonin.
Posted by undopaminergic on January 25, 2021, at 2:37:25
In reply to Re: parnate, posted by creepy on January 24, 2021, at 18:31:16
> I agree about the washout. But the doctors at this clinic are really ignorant of a lot of pharmacology, especially MAOI it took me a huge effort to even get emsam prescribed.
>
> Selegiline has stimulant qualities too for a short while then after that its kind of sleepy actually.
> Does parnate remain stimulating? Im guessing the sedation is a quality of all MAOI via melatonin.
>Phenelzine has a GABAergic metabolite, largely responsible for its calming and sedative effects; this is unlike tranylcypromine and selegiline. Selegiline has (l-) amphetamine metabolites, and tolerance easily develops, as happened to me. I would expect tranylcypromine too to produce tolerance.
-undopaminergic
This is the end of the thread.
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