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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by jay2112 on January 9, 2021, at 22:31:26
When Robin Williams committed suicide, the autopsy found massive decay, lewy body dementia. They were surprised he could even still walk!! My inability to just even sometimes make it through a day of doing *nothing* scares me. I am 51, I *want* it to get better...I don't do or threaten self-injury because I am GOING to get what I want. It's just certain drugs are not on my insurance formulary, and I can't afford to pay for them out-of-pocket. (I am in Canada...no public pharmacare).
What brain antioxidant is the most powerful and best??
Jay
Posted by Lamdage22 on January 9, 2021, at 22:47:42
In reply to Anyone concerned about Dementia??, posted by jay2112 on January 9, 2021, at 22:31:26
Possibly Glutathione followed by VItamin E. I am having GSH checked soon. If it is low I am going to take S-Acetyl-GLutatione
Posted by Lamdage22 on January 10, 2021, at 0:24:48
In reply to Re: Anyone concerned about Dementia??, posted by Lamdage22 on January 9, 2021, at 22:47:42
I am concerned, yeah. Neuroleptics don't help with that!
Posted by Lamdage22 on January 10, 2021, at 1:13:35
In reply to Re: Anyone concerned about Dementia??, posted by Lamdage22 on January 10, 2021, at 0:24:48
Thats what I am talking about. Dementia, Tardive Dyskinesia. If you get either one, would you still consider the meds that helpful, even if they are "effective"?
Posted by jay2112 on January 10, 2021, at 14:58:46
In reply to Re: Anyone concerned about Dementia??, posted by Lamdage22 on January 10, 2021, at 1:13:35
> Thats what I am talking about. Dementia, Tardive Dyskinesia. If you get either one, would you still consider the meds that helpful, even if they are "effective"?
Well, I DO have a slight amount of TD. My left hand shakes quite badly, when put under a bit of strain, sometimes. Other times, I just notice is mildly.
I think maybe when I took Prozac, it contributed to it, as well as when I was on Risperdal. But I have been on every typical antipsychotic, and a few typicals (for brief periods of time) since.
Knock on wood, TD hasn't been much of a problem.How about you, Lamdage22?
Jay
Posted by jay2112 on January 10, 2021, at 15:21:46
In reply to Re: Anyone concerned about Dementia??, posted by Lamdage22 on January 10, 2021, at 0:24:48
I guess I am concerned more with my benzo use. (Which is only occasionally)..but I have to take higher doses than prescribed, because over 30 years, I have developed tolerance. Rxlist.com suggests that doses as high as 4mg a day may be needed. I am prescribed 3mg a day, and will save them up to take 6mg in one shot, along with Inderal, if I am having a rough day. This IS NOT abuse..I don't take them for recreational purposes, but as part of my BP2/GAD diagnosis.
But, since greatly reducing my Effexor/antidepressant use, my memory has much improved. I think AD's are much more detrimental to good cognitive functioning. As a BP2'er, ad's, at high doses, even medium, impair my memory, cognition, and temperament. Combined with ad's, benzos greatly impair my memory. Lower my ad, and I better tolerate benzos. I think there may be a secret to very low dose ad's. I remember a time when I was on imipramine, at 10-20mg's and I did great! But, the doctor kept pushing for higher doses.
Anyhow, I am a bit afraid to take those tests for either Lewis Body or Alzheimer's disease/dementia.
Jay
Posted by Lamdage22 on January 10, 2021, at 22:13:02
In reply to Re: Anyone concerned about Dementia?? » Lamdage22, posted by jay2112 on January 10, 2021, at 14:58:46
My tongue is shaky and moves a bit when i stick it out. But it has been like this for years, it doesn't get worse.
> How about you, Lamdage22?
>
> Jay
>
Posted by Petermartin on January 12, 2021, at 23:35:52
In reply to Anyone concerned about Dementia??, posted by jay2112 on January 9, 2021, at 22:31:26
Very low dose Lithium (like microcodes that maybe should naturally exist in water) have been shown to help prevent cognitive decline.
https://www.medicalnewstoday.com/articles/can-lithium-halt-progression-of-alzheimers-disease
But yea, I'm a little concerned when it comes to mind.
Posted by Hugh on January 13, 2021, at 11:37:00
In reply to Anyone concerned about Dementia??, posted by jay2112 on January 9, 2021, at 22:31:26
> What brain antioxidant is the most powerful and best??
https://www.lifeextension.com/magazine/2020/ss/fisetin-a-senolytic-for-longevity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649683/
https://www.lifeextension.com/magazine/2007/10/report_curcumin
Petermartin's suggestion about microdosing lithium is a good one.
https://www.nytimes.com/2014/09/14/opinion/sunday/should-we-all-take-a-bit-of-lithium.html
Hope on the horizon:
https://medicalxpress.com/news/2021-01-hydrogen-sulfide-alzheimer-disease.html
Posted by SLS on January 19, 2021, at 21:18:42
In reply to Re: Anyone concerned about Dementia-Benzos, posted by jay2112 on January 10, 2021, at 15:21:46
I read a recent article that reports that neither benzodiazepines nor the Z-drugs increase one's risk for developing Alzheimer's Dementia. However, anticholinergics do.
- Scott
Posted by SLS on January 19, 2021, at 21:45:21
In reply to Re: Anyone concerned about Dementia??, posted by Hugh on January 13, 2021, at 11:37:00
Low-dosage lithium (300mg/day) improved my depression immediately, although not robustly, when it was added to Parnate. However, it consistently makes me feel worse at 450 mg/day or higher. For me, the dose-response curve is biphasic. It turns out that lithium's effect on glutamatergic activity also follows a biphasic curve. Low dosages increase glutamatergic activity while high dosages decrease it. Anyway, when it was unclear whether or not lithium was still having a positive effect on my mood, I elected to continue taking it regardless. The *only* reason why I continued to take lithium was because I had read about it possibly preventing Alzheimer's Dementia. I can't remember how many years I've been taking low-dosage lithium for. It has been at least 10 years.
At this point, my personal experience with lithium and at least one Harvard clinical study indicates that low dosages (300-600mg/day) are sufficient when treating unipolar depression. In fact, low dosages might actually be necessary. At 300mg/day, there are generally no side effects, and the risk of kidney or thyroid damage is negligible.
I am interested to know what other people have experienced with low-dosage lithium.
- Scott
Posted by Lamdage22 on January 20, 2021, at 0:49:16
In reply to Re: Anyone concerned about Dementia??, posted by SLS on January 19, 2021, at 21:45:21
Good stuf. It helps with suicidality at 225.
> I am interested to know what other people have experienced with low-dosage lithium.
>
>
> - Scott
Posted by creepy on January 20, 2021, at 15:15:43
In reply to Anyone concerned about Dementia??, posted by jay2112 on January 9, 2021, at 22:31:26
I am 50 also and I have had physical symptoms of depression in the last 10 years. cognitive and motor slowing, slow halting speech etc. and yes I really worry about dementia too.
symptoms of depression can become physical and mimic demetia. I had a doctor call this 'pseudo-dementia' awhile back.
What did resolve these symptoms for me (but not the emotional issues) was TMS.
I think the lack of activity and high carbohydrate intake thats common in depressives also contributes to the physical symptoms.
This is the end of the thread.
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