> Hi, NKP.
>
> How do interpret the results of this study as it relates to brain volume?
>
> Isn't brain inflammation common in depression? I never looked into the effects of antidepressants on brain inflammation. It may be that the association of depression and inflammation is not so easily explained. Which came first, the inflammation or the depressive state? After the induction of a mood illness, does a primary disease pathology and a pro-inflammatory reaction to it become self-reinforcing? Perhaps a positive-feedback loop accelerates the development of symptoms or makes the depression more robust and less likely to remit spontaneously.
>
>
> - Scott
Interesting, that sertraline was one the only one of all the antidepressants to be shown to be pro-inflammatory. Sertraline actually reminds me more of a cross between amphetamine and an antipsychotic. It does have stronger than most SSRI Dopamine reuptake properties, but the SRI part of the drug may counter-act? I dunno...
Jay
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