Posted by SLS on October 27, 2000, at 9:06:51
In reply to SLS - Was it Something I Said?, posted by Judy on October 26, 2000, at 15:51:44
Dear Judy,
You are being silly now.
NO WAY !!!!!!!!!!!!!!!!!!!!!!!!!!!
Please, the only thing I am right now is upset that I somehow gave you the idea that you have offended me. NO WAY!
"Sense"? The only sense you can count on me as having is non-sense.
Actually, I was hoping to read follow-posts myself! I have never heard of a Nardil patch. Where can I go to find out more about it?
Offhand, I don't know what advantages there would be with a patch transdermal delivery. I doubt it would make much difference in side effects, hypotension in particular, or metabolism in the liver. I'm not sure, but my guess is that the reason why a gradual delivery of selegiline may be advantageous is because less of it would be converted to other active compounds like l-amphetamine and methamphetamine. This might make a significant difference in the overall behavior of selegiline in the body and the concentrations of the unwanted metabolites in the brain. (Perhaps amphetamines cause a depletion of dopamine).
"PHARMACOKINETICS: Selegiline is administered orally and is readily absorbed from the GI tract and crosses the blood/brain barrier. Peak serum concentrations are found in 0.5-2 hours. The drug is rapidly and completely metabolized to three active derivatives with the following half-lives: N-desmethyldeprenyl, 2 hours; 1-amphetamine, 17.7 hours; and 1-methamphetamine, 20.5 hours. Selegiline is eliminated slowly by the kidneys; about 45% of a single 10 mg dose is eliminated in the urine as the three active metabolites in 48 hours."
- Scott"
> Adam (I wonder if he still lurks?)
I was wondering the same thing, Noa. Adam was much more successful on the patch than the oral doses.I'm still waiting for a Nardil patch. I know for a fact that they were being tested at McLean Hospital here in MA, but I can't find any info about it. I have my fingers crossed that one will eventually be approved and it will provide me the benefits without the side effects that made it necessary for me to give it up.
> Judy
"
> Scott,
>
> I left a message for you in the "High Doses of Parnate" thread and I had also hoped you'd 'sense' that I wanted your input on the "Nardil Patch" question that I squeaked into the "Selegiline Patch Update" thread.
>
> As soon as you tell me what I did to offend you, I promise never to do it again! : )
>
> Judy
poster:SLS
thread:47438
URL: http://www.dr-bob.org/babble/20001022/msgs/47501.html