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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by mila s on July 28, 2005, at 16:11:13
I went to the website linked below and it says:
"Homocysteine and SAMe are like two ends of a see-saw. What makes one go up, makes the other go down. So the same nutrient formula that helps fight depression, may have the beneficial side effect of reducing heart disease and stroke."
Isn't it the case that SAM-E breaks down into homocysteine? And that therefore it is suggested that one take B6, B12, TMG in order to convert the homocysteine back into SAM-E?
When I wrote to the website folks saying the information was misleading they replied:
"This article was written by a medical doctor who specializes in nutrition. Can you tell me your credentials?"
I'm thinking they must be very confident to respond that way. So perhaps I'm confused about the whole thing. Anyone care to comment?
The article is at:
http://www.energywave.com/what-ails-you/brain-functioning/nightmare.htm)
Posted by Declan on July 30, 2005, at 4:21:01
In reply to Is this misinformation about SAM-E, posted by mila s on July 28, 2005, at 16:11:13
I do know that after a couple of years on SAMe 400mg/d my homocysteine levels were quite fine. I would have been taking RDA levels X 2 of B6, folic acid and B12, or something like that. I had the same worry as you but my dr said he'd not seen that happen, some supplementation of B6, B12, and folic acid assumed.
Declan
Posted by Ktemene on August 6, 2005, at 21:45:38
In reply to Is this misinformation about SAM-E, posted by mila s on July 28, 2005, at 16:11:13
A few months ago JRBecker posted an article on an open study of SAM-e: "S-Adenosyl-L-Methionine (SAMe) as an Adjunct for Resistant Major Depressive Disorder: An Open Trial Following Partial or Nonresponse to Selective Serotonin Reuptake Inhibitors or Venlafaxine".
One of the things the researchers were looking for was before and after homocysteine levels. The reseachers concluded: "There was a significant but modest (4.9%) decrease in pretreatment to posttreatment homocysteine levels (from 8.2 ± 2.5 to 7.8 ± 2.3 µmol/L, t test; df = 22; P = 0.003)."
So this study suggests that you don't need to worry about SAM-e causing elevated homocysteine; in fact the study suggests that SAM-e will help decrease homocysteine levels. Of course, it is a small study and it needs to be confirmed by a larger study.
JRBecker's post and the article are at this URL:
poster:jrbecker thread:415835
URL: http://www.dr-bob.org/babble/alter/20041108/msgs/415835.html
> I went to the website linked below and it says:
>
> "Homocysteine and SAMe are like two ends of a see-saw. What makes one go up, makes the other go down. So the same nutrient formula that helps fight depression, may have the beneficial side effect of reducing heart disease and stroke."
>
> Isn't it the case that SAM-E breaks down into homocysteine? And that therefore it is suggested that one take B6, B12, TMG in order to convert the homocysteine back into SAM-E?
>
> When I wrote to the website folks saying the information was misleading they replied:
>
> "This article was written by a medical doctor who specializes in nutrition. Can you tell me your credentials?"
>
> I'm thinking they must be very confident to respond that way. So perhaps I'm confused about the whole thing. Anyone care to comment?
>
> The article is at:
> http://www.energywave.com/what-ails-you/brain-functioning/nightmare.htm)
This is the end of the thread.
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