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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Skeletor on June 6, 2020, at 20:03:50
https://en.wikipedia.org/wiki/Amitriptyline
https://en.wikipedia.org/wiki/Nortriptyline
Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite.
When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition)
What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically)
binding affinities: https://abload.de/img/nortgpk1f.png
Posted by Skeletor on June 7, 2020, at 12:27:23
In reply to Amitriptyline vs Nortriptyline, posted by Skeletor on June 6, 2020, at 20:03:50
Anyone had a chance to test them both?
This is the end of the thread.
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