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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 21 of 21. This is the beginning of the thread.
Posted by phidippus on December 6, 2019, at 21:18:39
I'm treating my bipolar depression and OCD with Trintellix. It's working wonders after about 6 weeks. My depression has faded and my OCD is attenuated. Has anyone here had any experiences with Trintellix?
Posted by sigismund on December 6, 2019, at 23:21:44
In reply to Trintellix..Have you tried it?, posted by phidippus on December 6, 2019, at 21:18:39
Nausea can be a problem?
Has it made you feel clearer? (I could do with that.)
OCD I understand. I'm less clear about depression.
I would try it.
Posted by linkadge on December 7, 2019, at 13:36:21
In reply to Trintellix..Have you tried it?, posted by phidippus on December 6, 2019, at 21:18:39
I'd like to, but no insurance....not an option.
Linkadge
Posted by phidippus on December 7, 2019, at 19:04:37
In reply to Re: Trintellix..Have you tried it?, posted by sigismund on December 6, 2019, at 23:21:44
No nausea.
I definitely feel clearer and vibrant. I have more motivation and positive thoughts abound.
Posted by sigismund on December 7, 2019, at 19:48:52
In reply to Re: Trintellix..Have you tried it?, posted by phidippus on December 7, 2019, at 19:04:37
>I definitely feel clearer and vibrant. I have more motivation and positive thoughts abound.
That's pretty good.
I recall someone (maybe SLS?) saying that higher doses may not be better?
I have never taken an SSRI, although many other ADs.
Posted by Lamdage22 on December 8, 2019, at 4:31:47
In reply to Trintellix..Have you tried it?, posted by phidippus on December 6, 2019, at 21:18:39
Congrats. It's good to hear a success story for a change.
Posted by undopaminergic on December 8, 2019, at 9:23:09
In reply to Trintellix..Have you tried it?, posted by phidippus on December 6, 2019, at 21:18:39
> I'm treating my bipolar depression and OCD with Trintellix. It's working wonders after about 6 weeks. My depression has faded and my OCD is attenuated. Has anyone here had any experiences with Trintellix?
>Vortioxetine (Brintellix where I live) has caught my attention, and I plan to try it next, if trimipramine (Surmontil) does not work out satisfactorily.
An interesting alternative is the antipsychotic lurasidone (Latuda). It is one of few drugs to be officially indicated for *bipolar* depression. It seems to produce some nootropic effects like vortioxetine. I planned to try it, but I decided on vortioxetine because one of the most frequent side effects was somnolence.
-undopaminergic
Posted by undopaminergic on December 8, 2019, at 9:47:15
In reply to Re: Trintellix..Have you tried it?, posted by sigismund on December 7, 2019, at 19:48:52
>
> I have never taken an SSRI, although many other ADs.
>Trintellix (vortioxetine) is not a *selective* serotonin reuptake inhibitor (SSRI) though it is a SRI. See: https://en.wikipedia.org/wiki/Vortioxetine#Pharmacology
-undopaminergic
Posted by SLS on December 8, 2019, at 13:42:05
In reply to Re: Trintellix..Have you tried it?, posted by sigismund on December 7, 2019, at 19:48:52
> >I definitely feel clearer and vibrant. I have more motivation and positive thoughts abound.
>
> That's pretty good.
>
> I recall someone (maybe SLS?) saying that higher doses may not be better?
>
> I have never taken an SSRI, although many other ADs.
My doctor and his buddies on newsgroups have seen more success using 10 mg/day than dosages above 20 mg/day.
- Scott
Posted by pedr on December 8, 2019, at 14:01:56
In reply to Re: Trintellix..Have you tried it? » phidippus, posted by undopaminergic on December 8, 2019, at 9:23:09
> > I'm treating my bipolar depression and OCD with Trintellix. It's working wonders after about 6 weeks. My depression has faded and my OCD is attenuated. Has anyone here had any experiences with Trintellix?
> >
>
> Vortioxetine (Brintellix where I live) has caught my attention, and I plan to try it next, if trimipramine (Surmontil) does not work out satisfactorily.
>
> An interesting alternative is the antipsychotic lurasidone (Latuda). It is one of few drugs to be officially indicated for *bipolar* depression. It seems to produce some nootropic effects like vortioxetine. I planned to try it, but I decided on vortioxetine because one of the most frequent side effects was somnolence.
>
> -undopaminergic
>Oh man, Surmontil was my first tricyclic and or made me sleep 14-16 hours a day, which double sucked because I have severe OCD about being depressed and sleeping all day is a sign of depression.
Anyway,I hope you fare better.
Pete
Posted by pedr on December 8, 2019, at 14:04:56
In reply to Trintellix..Have you tried it?, posted by phidippus on December 6, 2019, at 21:18:39
> I'm treating my bipolar depression and OCD with Trintellix. It's working wonders after about 6 weeks. My depression has faded and my OCD is attenuated. Has anyone here had any experiences with Trintellix?
Yes. No luck for me. Can't recall Any specifics other than it not denting my TRD.
Pete
Posted by SLS on December 8, 2019, at 14:09:53
In reply to Re: Trintellix..Have you tried it? » sigismund, posted by undopaminergic on December 8, 2019, at 9:47:15
> >
> > I have never taken an SSRI, although many other ADs.
> >
>
> Trintellix (vortioxetine) is not a *selective* serotonin reuptake inhibitor (SSRI) though it is a SRI. See: https://en.wikipedia.org/wiki/Vortioxetine#Pharmacology
>
> -undopaminergic
>
My doctor likes using Trintellix with his TRD patients.I've tried it twice. The trials were about a year apart. The results were the same for both trials. I experienced significant improvements episodically, but I couldn't get it to stick. In the end, the drug did more harm than good. It left me in a fog after its discontinuation that persisted for months. The worst part, though, was when I switched to Effexor. I became extremely suicidal upon starting at 37.5 mg/day. This never happened to me before with Effexor. I've been on it a handful of times. Perhaps Trintellix left my brain altered in a way that would produce such an effect.
Overall, my impression of Trintellix is that it is a powerful drug with few side effects that I think is worth considering.
- Scott
Posted by phidippus on December 10, 2019, at 16:19:32
In reply to Re: Trintellix..Have you tried it?, posted by SLS on December 8, 2019, at 14:09:53
>Trintellix left my brain altered in a way that >would produce such an effect.
I don't think any drugs leave the brain "altered". If they did, I'd be f*ck*d from all the LSD I took as a teenager and that's a powerful drug.
Posted by undopaminergic on December 11, 2019, at 8:44:04
In reply to Re: Trintellix..Have you tried it? » SLS, posted by phidippus on December 10, 2019, at 16:19:32
> >Trintellix left my brain altered in a way that >would produce such an effect.
>
> I don't think any drugs leave the brain "altered". If they did, I'd be f*ck*d from all the LSD I took as a teenager and that's a powerful drug.
>Sorry to say, but some drugs do in some cases; doesn't mean it happens to everyone.
For example, I still have some of the depersonalisation I got from reboxetine (Edronax) even though it's been over 15 years since I last took it.
Nicotine and cocaine-like stimulants also altered my brain. I prefer to call it "adaption" because it is an adaption of the brain to the condition produced by the drugs.
-undopaminergic
Posted by Christ_empowered on December 11, 2019, at 14:18:32
In reply to Re: Trintellix..Have you tried it? » phidippus, posted by undopaminergic on December 11, 2019, at 8:44:04
psych drugs can cause brain changes. there are horror stories about any and all psych drugs, but it seems that the neuroleptics--especially high doses--are the worst offenders. tardive akathisia, tardive psychosis, tardive dementia...
blah. :-(
Posted by linkadge on December 16, 2019, at 14:49:32
In reply to Re: Trintellix..Have you tried it? » SLS, posted by phidippus on December 10, 2019, at 16:19:32
>I don't think any drugs leave the brain "altered". >If they did, I'd be f*ck*d from all the LSD I took >as a teenager and that's a powerful drug.
I would disagree with that statement. I believe it is entirely possible for drugs to alter the brain. Sometimes this is for the positive (i.e neurotrophic effects), but sometimes this is negative (i.e. atrophy associated with typical antipsychotics).
Some medications can lead to changes that persist well beyond the administration of the drug. Nicotine, for example, can alter the epigenome for generations.
When drugs are administered in adolescence / early adulthood, I think the possibility of long term changes in increased.
Linkadge
Posted by beckett2 on January 12, 2020, at 15:06:10
In reply to Re: Trintellix..Have you tried it? » phidippus, posted by linkadge on December 16, 2019, at 14:49:32
>Some medications can lead to changes that persist well beyond the administration of the drug. Nicotine, for example, can alter the epigenome for generations.
This is fascinating.
Posted by creepy on January 13, 2020, at 20:31:35
In reply to Re: Trintellix..Have you tried it? » SLS, posted by phidippus on December 10, 2019, at 16:19:32
I am on 10mg vortioxetine. I dont really know how well it works because (im pretty damn sure) my liver is metabolizing it ridiculously fast or some other metabolic issue is to blame. The reason I say that is this drug has a half life of 66 hours and I am getting brain zaps when Im ready for the next dose 24 hours later.
sneaking in a CYP2D6 inhibitor like bupropion or desipramine helps a little. When I do either of those I feel better for a few hours then slowly get really irritable like I have pain somewhere I just cant put my finger on. I dont have lots of energy or hypo symptoms, just leave-me-the-hell-alone depression.
When it works the drug helps with the cognitive effects of depression a little.
Sorry to be so negative, hope this helps someone =/
Posted by beckett2 on January 13, 2020, at 23:09:08
In reply to Re: Trintellix..Have you tried it?, posted by creepy on January 13, 2020, at 20:31:35
> I am on 10mg vortioxetine. I dont really know how well it works because (im pretty damn sure) my liver is metabolizing it ridiculously fast or some other metabolic issue is to blame. The reason I say that is this drug has a half life of 66 hours and I am getting brain zaps when Im ready for the next dose 24 hours later.
> sneaking in a CYP2D6 inhibitor like bupropion or desipramine helps a little. When I do either of those I feel better for a few hours then slowly get really irritable like I have pain somewhere I just cant put my finger on. I dont have lots of energy or hypo symptoms, just leave-me-the-hell-alone depression.
> When it works the drug helps with the cognitive effects of depression a little.
> Sorry to be so negative, hope this helps someone =/
____________Hey, nice to see you. Did you switch from escitalopram to trintellix recently? If so, is it possible your symptoms are a withdrawal from the lexapro? Just a thought. Idk.
Posted by phidippus on January 14, 2020, at 11:58:10
In reply to Re: Trintellix..Have you tried it?, posted by creepy on January 13, 2020, at 20:31:35
I found 15 mg works a lot better than 10 mg.
Posted by creepy on January 14, 2020, at 17:20:50
In reply to Re: Trintellix..Have you tried it? » creepy, posted by beckett2 on January 13, 2020, at 23:09:08
Ive been through many drugs since citalopram. I did a trial of venlafaxine against my own better judgement and became suicidal on it. getting off of it was torture. I went from setraline to vortioxetine. brain zaps are occurring months later, so it is either vortioxetine, my metabolism or my brain has finally fried from all these stupid drugs.
This is the end of the thread.
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