![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 23 of 23. This is the beginning of the thread.
Posted by undopaminergic on December 22, 2019, at 8:17:47
This is a bit silly, but I'm curious:
If you could choose freely from any and all substances -- at least those known to science -- what would you use or try?
-undopaminergic
Posted by linkadge on December 22, 2019, at 14:28:04
In reply to If you could choose from *everything*, posted by undopaminergic on December 22, 2019, at 8:17:47
This sounds bad, but letting me have unlimited access to any medication would probably result in my demise :) But, I've often wondered the same thing myself.
Some combinations I'd like to try
- lithium + selegiline
- nardil + amitriptyline
- Ritalin + Trintellix + GHB
- venlafaxine + Mirapex
- quetiapine + Mirapex
- quetiapine + parnateI could go on
Linkadge
Posted by rjlockhart37 on December 22, 2019, at 16:47:12
In reply to Re: If you could choose from *everything* » undopaminergic, posted by linkadge on December 22, 2019, at 14:28:04
i'll be stright forward, but dexedrine during the day, and a barbiturate for sleep at night. Meprobamate for anxiety during the day. meprobamate is rarely used and it's not like benzos, it's an old sedative they usedd for a while, then they came out with benzos and it went out of the scene
mainy because dexedrine helps me function during the day, i work, read things i enjoy, better quality of life, but the only thing waas a porblem was when it wore off, i hated that period becuase dopamine levels drop and you feel like drained and washed out. The doctor i had didnt work with me with dosage timing, he just simply put me on 60mg of dex spansules, so i started taking 2 in the morning, and then 2 in after noon, which would be 12 hours, to help me function. without the spansule, it wears off in 3-4 hours and it feels like nasty
they used to use meprobamate combined with dexedrine back in the 60s for a antidepressant treatment.
barbiturates i already know, they would help sleep but i did research and you become tolerant to them, they will work well for like 4 weeks and then it loses it's effectiveness, seconal ... etc which would be a problem, so may just use a benzo.
that's my honest model that would help, but no doctor right now would do that. Just a recommendation for what i needed
Posted by sigismund on December 22, 2019, at 18:51:43
In reply to Re: If you could choose from *everything*, posted by rjlockhart37 on December 22, 2019, at 16:47:12
Some Dexedrine for special occasions. I have a lot of trouble with social occasions of any complexity and it would greatly help.
Posted by beckett2 on December 22, 2019, at 21:28:56
In reply to If you could choose from *everything*, posted by undopaminergic on December 22, 2019, at 8:17:47
> This is a bit silly, but I'm curious:
>
> If you could choose freely from any and all substances -- at least those known to science -- what would you use or try?
>
> -undopaminergic
>Without any fallout or addiction? Heroin.
Posted by sigismund on December 22, 2019, at 23:14:00
In reply to Re: If you could choose from *everything* » undopaminergic, posted by beckett2 on December 22, 2019, at 21:28:56
Haha
Dilaudid.
Posted by undopaminergic on December 23, 2019, at 0:41:31
In reply to Re: If you could choose from *everything* » beckett2, posted by sigismund on December 22, 2019, at 23:14:00
> Haha
>
> Dilaudid.
>Dilaudid (hydromorphone) is one of my choices too. I would be careful to attend to the issue of tolerance, finding a way a to prevent it, such as by taking it infrequently enough, or try combining with memantine or ketamine.
I would definitely try amineptine.
Perhaps the main thing I would try is selective dopamine reuptake inhibitors. Second most interesting option for me is tranylcypromine (Parnate). I might try high doses of rasagiline (I already tried it in low/regular doses).
I would try cocaine, but probably avoid smoking it.
I would experiment with other opioids than hydromorphone, including methadone, morphine, and oxymorphone. Perhaps try opioid rotation, to deal with tolerance.
Most modestly and realistically, I would try higher doses of trimipramine. As it is, this is the most realistic option.
Second most modestly, I would try vortioxetine (Brintellix, Trintellix).
I would try lithium, at least in lower doses.
I would try methamphetamine, but try to avoid chronic high doses, due to concerns about neurotoxicity.
I would try ketamine on its own.
I would try higher doses of scopolamine (already tried low doses -- Scopoderm). I would also try at least one other anticholinergic, orphenadrine.
I would probably try low doses of phencyclidine (PCP).
I would try some drugs I've already tried, including buprenorphine (Temgesic, Suboxone, Subutex). Also pramipexole (Sifrol, Mirapex). Maybe selegiline again too.
If necessary, I would try certain combinations, including some antipsychotics. Perhaps most promisingly, I would try (meth)amphetamine with tranylcypromine, if necessary to potentiate the latter.
-undopaminergic
Posted by linkadge on December 23, 2019, at 11:37:53
In reply to Re: If you could choose from *everything*, posted by undopaminergic on December 23, 2019, at 0:41:31
I love how most of the responses are 'addictive' drugs (myself included). Either we're all addicts, or there is some serious dysfunction (i.e. dopamine) that is simply not addressed by regular medications.
I took regular meds for close to 20 years (basically a zombie). I started using 'riskier' (potentially addictive) combinations in the past 2-3. For me, it got to the point of getting something to feel better NOW, or death.
Linkadge
Posted by sigismund on December 23, 2019, at 15:21:40
In reply to Re: If you could choose from *everything*, posted by undopaminergic on December 23, 2019, at 0:41:31
Chewing coca is pretty good. Like a double shot coffee, but better.
No downside to it, except that you can eventually feel a bit strung out after a lot.
Maybe microdosing psychedelics.
Posted by sigismund on December 23, 2019, at 15:26:45
In reply to Re: If you could choose from *everything* » undopaminergic, posted by linkadge on December 23, 2019, at 11:37:53
One of the best for me was NMN (NAD+ precursor). Unfortunately I could not continue for a side effect.
It felt so good I kept wondering why it was not restricted.
Posted by linkadge on December 23, 2019, at 16:53:05
In reply to Re: If you could choose from *everything*, posted by sigismund on December 23, 2019, at 15:21:40
>Chewing coca is pretty good. Like a double shot >coffee, but better.
Sounds good. Let's add that to my list too.
Linkadge
Posted by beckett2 on December 24, 2019, at 4:09:39
In reply to If you could choose from *everything*, posted by undopaminergic on December 22, 2019, at 8:17:47
More realistically, I want to give ketamine a serious go.
Posted by undopaminergic on December 24, 2019, at 6:32:54
In reply to Re: If you could choose from *everything* » undopaminergic, posted by linkadge on December 23, 2019, at 11:37:53
> I love how most of the responses are 'addictive' drugs (myself included).
>Oh, I thought your responses were pretty modest/cautious, although sure, some of your options (eg. Ritalin and Parnate) can be addictive to some people. Indeed, even quetiapine has been linked to drug-seeking behaviour.
> Either we're all addicts, or there is some serious dysfunction (i.e. dopamine) that is simply not addressed by regular medications.
>I'm pretty sure it's the latter. Even using drugs recreationally does not necessarily imply addiction.
> I took regular meds for close to 20 years (basically a zombie). I started using 'riskier' (potentially addictive) combinations in the past 2-3. For me, it got to the point of getting something to feel better NOW, or death.
>I've been through that phase. I took stimulants to ward off suicidal ideation. Now, I'm in a better condition, and I rarely even long for stimulants most of the time.
-undopaminergic
Posted by undopaminergic on December 24, 2019, at 7:12:03
In reply to Re: If you could choose from *everything*, posted by sigismund on December 23, 2019, at 15:21:40
> Chewing coca is pretty good. Like a double shot coffee, but better.
>
> No downside to it, except that you can eventually feel a bit strung out after a lot.
>There is also coca tea, mate de coca.
You can "simulate" coca leaf by taking a little "pure" cocaine into your mouth and let it get absorbed through the mucous membranes. Alternatively, add a small pinch of cocaine to your tea or coffee -- indeed, why not Coca-Cola?
> Maybe microdosing psychedelics.
>I read that that can have nootropic effects.
What about low dose naltrexone (LDN)?
-undopaminergic
Posted by linkadge on December 24, 2019, at 7:49:01
In reply to Re: If you could choose from *everything* » linkadge, posted by undopaminergic on December 24, 2019, at 6:32:54
I came off Ritalin for stupid reasons (I was taking 4 meds and could only afford 3). I chose to stay on lithium, Effexor and mirtazapine and drop Ritalin. I have relapsed in many ways coming off of it.
I have lost confidence in my ability to get things done. This has filtered through to my job choices (turning down decent jobs that require a lot of paperwork / deskwork). In some ways this may not have been a bad idea (sitting for long periods of time on stimulants can't be great for the body). However, depression has returned as small tasks take me FOREVER to get done.
The only time I can sit to watch a movie is when I am using pot. Although a bit impractical, certain doses of THC do actually improve my attention / hyperactivity.
Linkadge
Posted by undopaminergic on December 24, 2019, at 8:02:21
In reply to Re: If you could choose from *everything* » undopaminergic, posted by linkadge on December 24, 2019, at 7:49:01
> I came off Ritalin for stupid reasons (I was taking 4 meds and could only afford 3). I chose to stay on lithium, Effexor and mirtazapine and drop Ritalin. I have relapsed in many ways coming off of it.
>
> I have lost confidence in my ability to get things done. This has filtered through to my job choices (turning down decent jobs that require a lot of paperwork / deskwork). In some ways this may not have been a bad idea (sitting for long periods of time on stimulants can't be great for the body). However, depression has returned as small tasks take me FOREVER to get done.
>
> The only time I can sit to watch a movie is when I am using pot. Although a bit impractical, certain doses of THC do actually improve my attention / hyperactivity.
>
>
> LinkadgeI wonder about the mirtazapine... it is an antagonist at alpha2-adrenoceptors. Meanwhile, guanfacine (Intuniv, Tenex) is an *agonist* at these receptors, improves working memory, and is used for ADHD. In other words, mirtazapine may be anti-cognitive, especially if you have ADHD.
I've read that vortioxetine (Brintellix, Trintellix) and lurasidone (Latuda) are pro-cognitive. In fact, I've read this about low-dose lithium as well.
-undopaminergic
Posted by linkadge on December 24, 2019, at 14:32:41
In reply to Re: If you could choose from *everything* » linkadge, posted by undopaminergic on December 24, 2019, at 8:02:21
Mirtazapine has been shown to improve cognition as an add on to antipsychotics in schizophrenia. Some of this could be related to other actions of mirtazapine, however.
Linkadge
Posted by sigismund on December 25, 2019, at 15:14:57
In reply to Re: If you could choose from *everything* » sigismund, posted by undopaminergic on December 24, 2019, at 7:12:03
>What about low dose naltrexone (LDN)?
I have thought of it but never tried it. Have you?
Posted by Lamdage22 on December 25, 2019, at 17:28:24
In reply to Re: If you could choose from *everything* » linkadge, posted by undopaminergic on December 24, 2019, at 6:32:54
I would like to give low dose phenytoin a try.
Posted by undopaminergic on December 25, 2019, at 17:42:15
In reply to Re: If you could choose from *everything* » undopaminergic, posted by sigismund on December 25, 2019, at 15:14:57
> >What about low dose naltrexone (LDN)?
>
> I have thought of it but never tried it. Have you?
>No, I haven't. To begin with, I should read more about it.
-undopaminergic
Posted by sigismund on December 25, 2019, at 20:37:12
In reply to Re: If you could choose from *everything* » sigismund, posted by undopaminergic on December 25, 2019, at 17:42:15
I assumed it would not help with sleep, at least to begin with.
Posted by Lamdage22 on December 27, 2019, at 7:17:43
In reply to Re: If you could choose from *everything* » undopaminergic, posted by sigismund on December 25, 2019, at 20:37:12
Free supplements!
Posted by greg rizzo on January 9, 2020, at 21:27:01
In reply to Re: If you could choose from *everything* » undopaminergic, posted by linkadge on December 24, 2019, at 7:49:01
Provigil, modafinil,nuvigil (extended release formula (all pretty much the same thing, were developed for narcolepsy (when people can't stay awake).
I have been using it for over a year and I cannot describe how truly amazing it is for depression. I am amazed more psych docs don't recommend it for other than narcolepsy,To save time just google it, but basically increases seratonin and dopamine. It works immediately, is entirely legal (usually need script but I have ways around that). Otherwise very expensive. Take early in am or you'll have trouble sleeping. I have told very few people about this drug--just joined psych-babble.
The source I use is a covert secret--"tell ya but then I'd have to kill ya." Kidding of
course!
On a scale of 1 to 10 for immediate relief of depression and more energy I give it a 10. It's that good.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.