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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by phidippus on December 17, 2019, at 18:11:36
Anyone care to share?
Posted by beckett2 on December 17, 2019, at 21:14:13
In reply to Name some glutamate inhibitors...Go!, posted by phidippus on December 17, 2019, at 18:11:36
Lamotrigine?
Posted by sigismund on December 17, 2019, at 21:23:27
In reply to Re: Name some glutamate inhibitors...Go! » phidippus, posted by beckett2 on December 17, 2019, at 21:14:13
Campral?
Posted by undopaminergic on December 18, 2019, at 7:04:20
In reply to Re: Name some glutamate inhibitors...Go!, posted by sigismund on December 17, 2019, at 21:23:27
Memantine, nitrous oxide (laughing gas), xenon, phencyclidine (PCP), ketamine, dextromethorphan (DXM) and its metabolite dextrorphan. Amantadine a bit (memantine is dimethylamantadine).
-undopaminergic
Posted by beckett2 on December 18, 2019, at 11:48:38
In reply to Re: Name some glutamate inhibitors...Go!, posted by undopaminergic on December 18, 2019, at 7:04:20
I hate nitrous oxide. Neither here nor there, just saying.
Posted by sigismund on December 18, 2019, at 15:03:43
In reply to Re: Name some glutamate inhibitors...Go! » undopaminergic, posted by beckett2 on December 18, 2019, at 11:48:38
I get glutamate mixed up with NMDA.
Posted by phidippus on December 18, 2019, at 22:17:31
In reply to Re: Name some glutamate inhibitors...Go!, posted by sigismund on December 18, 2019, at 15:03:43
NMDA is a glutamate receptor.
Posted by undopaminergic on December 19, 2019, at 6:55:01
In reply to Re: Name some glutamate inhibitors...Go! » sigismund, posted by phidippus on December 18, 2019, at 22:17:31
> NMDA is a glutamate receptor.
Yes. It is named after an amino acid, N-Methyl-D-Aspartate, which is an agonist at the receptor.
There are also AMPA, kainate, and metabotropic glutamate receptors. Metabotropic is as opposed to ionotropic, and there are several subtypes of them.
-undopaminergic
Posted by sigismund on December 19, 2019, at 10:36:49
In reply to Re: Name some glutamate inhibitors...Go! » phidippus, posted by undopaminergic on December 19, 2019, at 6:55:01
Piracetam and the like wok on AMPA?
Reliably made me feel worse.
Posted by undopaminergic on December 20, 2019, at 7:13:48
In reply to Re: Name some glutamate inhibitors...Go!, posted by sigismund on December 19, 2019, at 10:36:49
> Piracetam and the like wok on AMPA?
>
> Reliably made me feel worse.I don't know about piracetam, but aniracetam at least. I think that was kind of a prototype for the ampakines. There is some evidence that piracetam enhances acetylcholine.
The first time I tried piracetam, I seem to recall it made me a little irritable but at the same time, it was as if my mood was better.
-undopaminergic
Posted by sigismund on December 21, 2019, at 15:45:26
In reply to Re: Name some glutamate inhibitors...Go! » sigismund, posted by undopaminergic on December 20, 2019, at 7:13:48
As you'd know there is some argument about how acamprosate works......whether it is the Ca+ (which puzzled me) or whether it antagonises glutamate (I may be wrong).
It's of some use to help me to drink moderately long term. 2 about lunch time so I can wait until late afternoon.
Any comments?
Posted by sigismund on December 21, 2019, at 16:03:54
In reply to Re: Name some glutamate inhibitors...Go! » sigismund, posted by undopaminergic on December 20, 2019, at 7:13:48
I don't like acetylcholine increased or decreased. I either feel somewhat wired or hate the anticholinergic effect.
I forget what it was, a smart drug from years ago that was supposed to clear up cellular waste and therefore.......
Anyway I took that and it was a big race day. I had a tip and it almost made me manic. I didn't like it at all. Doubled the last bet and lost the lot.
I need something for my memory .
Posted by sigismund on December 21, 2019, at 16:09:31
In reply to Re: Name some glutamate inhibitors...Go! » undopaminergic, posted by sigismund on December 21, 2019, at 16:03:54
That was centrophenoxine.
This is the end of the thread.
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