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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on July 16, 2018, at 14:56:35
I honestly think that Effexor IR (once daily) works better for me than XR.
I know that the half life is short, but I'm not noticing any withdrawal by taking the IR version once daily.
Also, I get more hours in the day where I don't feel drugged.
Does an antidepressant really need to be in your system 24h a day to work?
Linkadge
Posted by Christ_empowered on July 16, 2018, at 16:34:45
In reply to Effexor IR, posted by linkadge on July 16, 2018, at 14:56:35
hi. i would think it wouldn't matter too much...antidepressants require a while to make changes in brain chemistry and such, so its not the same as a sedative, tranquilizer, or stimulant.
do you think maybe its an effect of the ir that helps? mildly stimulating, a bit sedating, etc.? im reminded of a friend who said the 3x daily, old school wellbutrin was better for her than the xl or whatever they call the 1x daily.
Posted by linkadge on July 16, 2018, at 17:14:41
In reply to Re: Effexor IR, posted by Christ_empowered on July 16, 2018, at 16:34:45
The XR just leaves me apathetic most of the day.
With the IR, I'm noticing a bit more yin-yang. My brain seems to get a break from the drug for a while, and I can feel a bit more.
Linkadge
Posted by bleauberry on July 19, 2018, at 8:50:32
In reply to Effexor IR, posted by linkadge on July 16, 2018, at 14:56:35
Well, I got the best response to some psychiatric meds at doses that were 1/10th to 1/2 of the lowest dose you can buy. I also did well on IR but not XR, but sometimes the opposite.
Right now the closest things to psychiatric meds I take are Rhodiola Rosea and St Johns Wort. Both of them are doing good work for me. But both are at very small doses. Most people do 500mg+ of Rhodiola - 100mg is my dose. Most people do 900mg of SJW - my best dose is just 150mg.
So I can feel that dose of SJW despite being so small. And I'm sure it wears off within 24 hours. rhodiola too. But it doesn't matter somehow. The mood improvement stays.
So I don't know, I think there are so many mysteries having to do with dose sizes, generic versus brand, IR versus XR, and such, I honestly think our scientific community is very weak on all this stuff. They really have no clue. You and me have a lot of questions they cannot answer. You and me experience things they cannot explain.
> I honestly think that Effexor IR (once daily) works better for me than XR.
>
> I know that the half life is short, but I'm not noticing any withdrawal by taking the IR version once daily.
>
> Also, I get more hours in the day where I don't feel drugged.
>
> Does an antidepressant really need to be in your system 24h a day to work?
>
> Linkadge
>
This is the end of the thread.
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