![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by zonked on July 2, 2010, at 20:24:54
You'd think since (most) sedatives, stimulants, and some pain medications can be evaluated as to whether or not they'll work the same day they are tried, that scientists would be able to come up with antidepressants that could be evaluated the same day as well.
I wonder why we don't have ADs like this. My whole being is getting tired of trials.
:/
-z
Posted by Phillipa on July 2, 2010, at 20:44:14
In reply to Why can't we have antidepressants that work (or not) the same day?, posted by zonked on July 2, 2010, at 20:24:54
Definitely agree. Coldn't agree more and makes so much sense. Makes you wonder? Phillipa ps could side effects be considered the med working and having a negative effect and then when body gets used to this it just kind of accepts? Phillipa
Posted by Conundrum on July 2, 2010, at 22:50:11
In reply to Why can't we have antidepressants that work (or not) the same day?, posted by zonked on July 2, 2010, at 20:24:54
if antidepressants worked in one day they would be too addictive to be on the market. Just got to a site like revolutionhealth.com and the top rated drugs are dexedrine, ultram, and ritalin.
(I'm not counting luvox since one person made 5 of the same entries which gave it a falsely high rating.)If its not sorted by highest rated to lowest click the user rating button.
Mirtazapine is the first standard new type of antidepressants on the list and it comes in at number 10.
Posted by bleauberry on July 4, 2010, at 13:07:05
In reply to Why can't we have antidepressants that work (or not) the same day?, posted by zonked on July 2, 2010, at 20:24:54
Because they are not addressing the real problem.
Someone with low serotonin is going to feel a whole lot better within hours or days on lex, zoloft, or prozac. If it isn't low, then it will take weeks or months for some other downstream adaptations to happen. Whether or not that is a good thing is another story.
Other circuits low, ritalin will work fast. If it doesn't, wrong circuits.
And so on.
Cholinergic activity too strong, a TCA should work fast.
Infections. Lyme, lyme-like, candida, others....their normal toxic excretions as well as their dying toxins have a molecular structure similar to our own endorphins, so they have an affinity for our opioid receptors. Effectively blocking our own feelgood chemicals from their destination sites, replacing them with toxinis. With a pain med like vicidin, it has stronger affinity for the opioid receptor than the toxin.. Thus the toxin is displaced. These patients do not normally get high on an opioid, but instead feel "normal" rapidly. Healthy people will instead experience either euphoria or dysphoria, but not normalcy.
When an antidepressant doesn't work fast, it is simply because it is doing the wrong thing for that person, missing the target.
Since it is all guesswork, we don't know what the target is.
Depression is intricately linked with the immune system, cortisol, thyroid, and other hormones. Every drug may have some downstream effect on one or more of these. Not necessarily the kind that shows up in a lab test, but more in the receptor sensitivity/affinity/response spectrum. This kind of depression will respond rapidly to the correct choice of hormone therapy, but slowly to a different drug that has a downstream effect.
And these are purely my views so don't ask me to prove anything. Nothing in psychiatry can be proved.
We spend 99% of our time looking at serotonin, norepinephrine, and dopamine as the depression guys. That's why antidepressants don't work fast or at all. Because those 3 neurotransmitters are but a small group in a larger crowd of depression causers.
Again, opinions here, for thought or discard.
Posted by zonked on July 4, 2010, at 18:18:28
In reply to Re: Why can't we have antidepressants that work (o, posted by bleauberry on July 4, 2010, at 13:07:05
Amen, buddy.
Let's just hope and pray that all of us who are treatment resistant can survive until the diagnostic process is where it should be.
Sometimes, I think if not for this board, I would have given up.
Does anyone know what percentage the highly treatment resistant are, of the entire depressed population? (Unipolar, bipolar, and otherwise.)
-z
Posted by bleauberry on July 5, 2010, at 16:03:45
In reply to Re: Why can't we have antidepressants that work (o » bleauberry, posted by zonked on July 4, 2010, at 18:18:28
We can't afford to wait that long. Life is too short. We have to do it ourselves. It isn't that hard. A few well chose trials can paint a good picture of what's going on. And I'm not talking just psych meds. The most dramatic thorough remissions I've ever seen were from antibiotics or DMSA.
> Amen, buddy.
>
> Let's just hope and pray that all of us who are treatment resistant can survive until the diagnostic process is where it should be.
>
> Sometimes, I think if not for this board, I would have given up.
>
> Does anyone know what percentage the highly treatment resistant are, of the entire depressed population? (Unipolar, bipolar, and otherwise.)
>
> -z
Posted by jade k on July 10, 2010, at 15:57:28
In reply to Re: Why can't we have antidepressants that work (or not) the same day? » zonked, posted by Conundrum on July 2, 2010, at 22:50:11
Because then the "happy" people wouldn't have anyone to compare themselves to.
I want a med that works...
And actually...NOW would be nice!
Any outside the seratonin box dopamine type meds out there working?
~Jade
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.