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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by linkadge on May 25, 2010, at 13:58:20
I was thinking about the activity of ketamine. It works as an NMDA antagonist with some dopamine and serotonin reuptake inhibition as well as mild MAOI effect.
I wonder if combing zinc or magnesium with low dose methylphendiate and SSRI would repicate this.
I remember reading a study in which zinc dramatically increased the ability of methylphenidate to inhibit the dopamine transporter.
Linkadge
Posted by bleauberry on May 25, 2010, at 17:49:41
In reply to replicating ketamine depression effect, posted by linkadge on May 25, 2010, at 13:58:20
I don't think anything is going to replicate what the ketamine molecule does. It's all just too complicated. What we know about a drug is in my guess probably only 10% of what there is to know.
But it would not surprise me at all if a formula of a particular med with particular supplements worked amazingly well.
The theory does make sense, that is, assuming someone thinks an NMDA antagonist is an antidepressant for them. For me, not. That mechanism is very pro-depressant to me.
Posted by linkadge on May 25, 2010, at 20:25:13
In reply to Re: replicating ketamine depression effect, posted by bleauberry on May 25, 2010, at 17:49:41
Well, I am assuming both of us haven't tried many selective NMDA antagonists. Both zinc and magnesium have many secondary effects. Magnesium tends to lower BDNF while zinc does the opposite.
I don't find magnesium to be antidepressant but I do find low doses of zinc to be.
There is some target of ketamine which is very fast acting (i.e. virtually immediate). Zinc does have acute antidepressant effects in anmial models (unlike imipramine which takes weeks for the AD effect to be observed).
Linkadge
Posted by Phillipa on May 25, 2010, at 23:37:55
In reply to Re: replicating ketamine depression effect, posted by linkadge on May 25, 2010, at 20:25:13
Zinc antidepressant? Phillipa
This is the end of the thread.
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