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Dr. Bob is Robert Hsiung, MD,
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Posted by whymelord on April 30, 2010, at 12:25:43
How do Ativan Xanax et al effect Dopamine (or other neurotransmitters cept of course GABA) which could explain the subtle euphoria they produce? Also is the sedative and amnesic effect just a start up symptom?
Posted by Phillipa on April 30, 2010, at 13:27:36
In reply to Whats the effect of Benzodiazepines on Dopamine etc?, posted by whymelord on April 30, 2010, at 12:25:43
In 40 years of benzo use never euphoria. So I seriously don't know. Phillipa
Posted by linkadge on April 30, 2010, at 13:39:41
In reply to Re: Whats the effect of Benzodiazepines on Dopamine etc? » whymelord, posted by Phillipa on April 30, 2010, at 13:27:36
Its completex. Some of the benzos have direct opioid binding effects (like xanax).
I think they can cause a release of dopamine in the neucleus accumbens but gaba-a agonists can degrease dopamine release in certain limbic regions too. Doctors have noted that in certain cases of schizophrenia, benzo's can treat acute flare ups as well as antipsychotics. And benzos like clonazepam have documented antimanic effects. I think the benzo's can induce a sense of well being, possibly due to effects on the opiate system, but its not the same kind of euphoria that stimulants give - i.e. massive power trip dopamine rush.
To answer your question. I dunno.
Linkadge
Posted by ed_uk2010 on April 30, 2010, at 13:58:44
In reply to Whats the effect of Benzodiazepines on Dopamine etc?, posted by whymelord on April 30, 2010, at 12:25:43
> How do Ativan Xanax et al effect Dopamine (or other neurotransmitters cept of course GABA) which could explain the subtle euphoria they produce? Also is the sedative and amnesic effect just a start up symptom?
The sedative effect tends to wear off in time. The effects on memory are very persistent - little tolerance develops.
This is the end of the thread.
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