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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by g_g_g_unit on December 30, 2009, at 17:42:15
has there been any consensus on the pathways implicated in RLS? outside of ferritin/magnesium levels etc. are there any other potential biological markers to weed out?
i always experience this as a side-effect of AD's - a strange, numb pressure in my legs during the day which tends to graduate in intensity at night. usually weaning off the offending drug abolishes the symptoms, but lately they've been hanging around indefinitely. my doc wanted to try klonopin but that didn't seem like a stable solution. i exercise and stretch regularly, which helps a bit.
i know it's compromising my sleep quality, which in turn affects my daytime performance. i want to try stimulants for general malaise, concentration difficulties, etc. but feel like anything which worsens RLS would just feed the problem.
would dexedrine - as a dopamine release(?) - potentially aggravate the problem? do its actions crossover with the pathways implicated in RLS at all?
sigh
Posted by Phillipa on December 30, 2009, at 18:39:15
In reply to dopamine, stimulants + restless leg, posted by g_g_g_unit on December 30, 2009, at 17:42:15
Lyrica? Phillipa
Posted by floatingbridge on December 30, 2009, at 22:09:33
In reply to dopamine, stimulants + restless leg, posted by g_g_g_unit on December 30, 2009, at 17:42:15
ggg,I can't answer your question regarding rls pathways. I'm wondering if dex has a short half life and that might make a trial less risky.
PS if you do decide to add it to your
regime, I've found the spansuals better than the IR for avoiding mood peaks and
valleys. (You did mention this on another post I think.)fb
Posted by g_g_g_unit on December 30, 2009, at 23:11:46
In reply to Re: dopamine, stimulants + restless leg » g_g_g_unit, posted by floatingbridge on December 30, 2009, at 22:09:33
>
> ggg,
>
> I can't answer your question regarding rls pathways. I'm wondering if dex has a short half life and that might make a trial less risky.
>
> PS if you do decide to add it to your
> regime, I've found the spansuals better than the IR for avoiding mood peaks and
> valleys. (You did mention this on another post I think.)
>
> fbthanks for your post fb. unfortunately, only Dex IR is available where i live.
this is all idle hypothesizing anyway. i feel so tired, listless and nihilistic that i can't even bring myself to arrange a doctor's appointment to begin the trial. no psych within a comet's reach will use stimulants off-label here, so i have to see some GP an hour's drive away to have them prescribed. but even then, i feel like they're only a temporary solution, and if they do work but increase anxiety/depression, this dude won't really be into augmenting (he treats pretty vanilla ADD cases). i mean, how the 'feck do i even broach the Memantine thing with him.
i'm tired of having to lie to doctors just to afford myself the best treatment i can. i'm tired of having to manage this all myself because some dolt doesn't understand how high doses of SSRI's and antipsychotics (the the only OCD treatment i'm afforded) could worsen motivational/cognitive issues. i'm 24. i wish i never knew what a friggen receptor was.
sorry [/vent]
Posted by floatingbridge on December 31, 2009, at 0:52:05
In reply to Re: dopamine, stimulants + restless leg » floatingbridge, posted by g_g_g_unit on December 30, 2009, at 23:11:46
GGG,
I'm sorry, ggg. No apologies needed for the vent--a little venting is good--I'm unhappy that you're in such a tight spot.
Can you get someone to drive you? Sounds like you need some support.
I love the expression you used, 'within a
comet's reach'. Made me smile despite
the content of your post.hugs,
fb
Posted by g_g_g_unit on December 31, 2009, at 2:33:32
In reply to Re: dopamine, stimulants + restless leg » g_g_g_unit, posted by floatingbridge on December 31, 2009, at 0:52:05
> GGG,
>
> I'm sorry, ggg. No apologies needed for the vent--a little venting is good--I'm unhappy that you're in such a tight spot.
>
> Can you get someone to drive you? Sounds like you need some support.
>
> I love the expression you used, 'within a
> comet's reach'. Made me smile despite
> the content of your post.
>
> hugs,
>
> fbthanks :)
what sucks (in a way) is that it's impossible for me to reach a full-blown breakdown. i keep waiting for it to hit, but everyday i wake up with (enough) energy to keep up appearances, make it through the day, etc. but not really function in the way i'd hope to (i guess that's the definition of dysthymia? it's like a volcano which never seems to explode).
so even though my post sounds hopeless - it's true that i am, but there's no real emotional anguish. it's more just concentration/drive issues mixed with a feeling of, well,"i give up". in its own peculiar way, it beats living with constant, life-or-death anxiety.
getting to the doctor isn't the problem. it's more like, oh great another med, what if it doesn't work, and if it does how will i get a psych to prescribe it etc. etc.
This is the end of the thread.
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