![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by linkadge on November 22, 2009, at 19:54:19
posits that theraputic antidepressants produce a mild shock to the system enabling it to increase its resistance to more severe stressors.
Antidepressants, ECT, exercise, all increase proteins (BDNF, HSP, BCL-2) in the brain that serve to protect it from other stressors. Even things like sleep deprivation or cold showers are mild stressors that may produce the same effects.Antidepressants seem to work in other models of neurodegeneration such as Huntingon's perhaps through the same mechanisms.
This may also explain AD poopout. I.e. after the brain becomes accustomed to the drug, it no longer sees it as foregin and therefore no longer needs to protect itself against this. This may also explain why reinitiation of certain drugs sometimes fails to work (i.e. the body no longer sees it as toxic).
In higher doses AD's can be highly cytotoxic, as can things like resveratrol. But at the right doses they turn on the resistance switches.
Linkadge
Posted by linkadge on November 22, 2009, at 19:59:22
In reply to The 'mild stressor' theory, posted by linkadge on November 22, 2009, at 19:54:19
Perhaps too this is why some people need to change their drug all the time. Its not necessarily a placebo effect per se, but that the precieved neurological changes are enough to kick the brain back into survival mode.
Linkadge
Posted by Phillipa on November 22, 2009, at 21:20:57
In reply to Re: The 'mild stressor' theory, posted by linkadge on November 22, 2009, at 19:59:22
Same or opposite of autoimmune diseases. Phillipa body sees as foreign rejects if good auto immune system. If it's not up to par maybe it takes two or more tries before it rejects it as foreign. So if you have autoimmune disease it's rejected and no response.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.