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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by linkadge on November 15, 2009, at 7:51:49
I've noticed over the years something strage about me. I don't sweat at all.
Now I've never been too woried about it, but its just strange. When I go jogging with others of my age, weight and fitness level, they finish drenched and I don't have a drop of sweat on me.
Even on boiling days in the summer.I don't want to read into things but could this be due to some sort of cholinergic dysregulation?
Linkadge
Posted by bulldog2 on November 15, 2009, at 9:06:11
In reply to I don't sweat, posted by linkadge on November 15, 2009, at 7:51:49
> I've noticed over the years something strage about me. I don't sweat at all.
>
> Now I've never been too woried about it, but its just strange. When I go jogging with others of my age, weight and fitness level, they finish drenched and I don't have a drop of sweat on me.
> Even on boiling days in the summer.
>
> I don't want to read into things but could this be due to some sort of cholinergic dysregulation?
>
>
> Linkadge
>
>wow never heard of anything like that! Ever tell a doctor? Sometimes the physical symtpoms such as this symtom could be a key to your emotional state.
Posted by Phillipa on November 15, 2009, at 10:42:47
In reply to Re: I don't sweat, posted by bulldog2 on November 15, 2009, at 9:06:11
Link I don't sweat either never have. Dr Oz was on TV has a show and said some don't have the same amount of sweat glands. Do you sweat after the cool down period and drink lots of fluids. I take that back Oz said smelly sweat glands. Still I don't sweat when others do they used to say that sweating besides cooling was removing toxins from the body and I assumed I didnt have them. Now this was years ago. Love Phillipa
Posted by Phillipa on November 15, 2009, at 12:56:51
In reply to Re: I don't sweat, posted by Phillipa on November 15, 2009, at 10:42:47
Link maybe this will shed some light. Phillipa
Posted by southernsky on November 15, 2009, at 20:47:01
In reply to I don't sweat, posted by linkadge on November 15, 2009, at 7:51:49
When I took Effexor, I had excessive sweating. Never had problems aside from that, but sweat regulation could be norephinephrine related, or related to hypothalamic dysfunction. Have you taken your temperature lately?
Dehydration is caused by lots of meds, which you already know. But I would take it more seriously, as someone said, symptoms like that could be related to mental health. Hope you get this checked by your doc.
There's a name for the condition.
http://en.wikipedia.org/wiki/Anhidrosis
Journal: Archives of Neurology
We studied a 66-year-old woman with spontaneous periodic hypothermia (Shapiro's syndrome) to determine the mechanisms that result in increased plasma norepinephrine (NE) levels. In comparison with age-matched control subjects, compartmental analysis of NE kinetics revealed an increased NE release rate into the extravascular compartment and decreases in NE clearance and volume of distribution of NE in the intravascular compartment. Clonidine therapy was associated with an initial dramatic decrease in the frequency of diaphoretic episodes as well as with a fall in NE release rate and increases in NE clearance and volume of distribution. We conclude that increased NE release and decreased plasma NE clearance result in elevated plasma NE levels in Shapiro's syndrome. Clonidine, which was associated with changes in NE kinetics, may provide effective treatment for this disorder.
http://en.wikipedia.org/wiki/Hypothalamus
Vey few cases of Shapiro's syndrome describe endocrine abnormalites. Abnormal thermoregulation is thought to be due to hypothalamic dysfunction. We suggest in our case that hypothalamic dysfunction may also cause abnormalities of water balance that mimic resetting of osmoreceptors. The significant appetite disturbance, which has not previously been described in Shapiro's syndrome may also be secondary to hypothalamic dysfunction.
Posted by southernsky on November 15, 2009, at 20:58:11
In reply to I don't sweat, posted by linkadge on November 15, 2009, at 7:51:49
Just be careful!
Drugs that induce hypohidrosis, or deficient sweating, can increase the risk of heat exhaustion or heat stroke and include antimuscarinic anticholinergic agents, carbonic anhydrase inhibitors and tricyclic antidepressants. As acetylcholine is the principal neuroeccrine mediator, anhidrosis is one of the clinical hallmarks by which acute anticholinergic toxicity may be recognized. The symptom of dry mouth often accompanies the less apparent symptom of hypohidrosis because the muscarinic M3 acetylcholine receptor type predominates at both sweat and salivary glands. Management options include dose reduction, drug substitution or discontinuation. When compelling medical indications require continuation of a drug causing hyperhidrosis, the addition of a pharmacological agent to suppress sweating can help to reduce symptoms. When hypohidrotic drugs must be continued, deficient sweating can be managed by avoiding situations of heat stress and cooling the skin with externally applied water. The availability of clinical tests for the assessment of sudomotor dysfunction in neurological disease has enhanced recognition of the complex effects of drugs on sweating. Advances in the understanding of drug-induced anhidrosis have also enlarged the therapeutic repertoire of effective treatments for hyperhidrosis.
http://www.ingentaconnect.com/content/adis/dsf/2008/00000031/00000002/art00002
DISORDERS OF SWEATING AND THERMOREGULATION.Article
CONTINUUM: Lifelong Learning in Neurology. 13(6) Autonomic Disorders:143-164, December 2007.
Cheshire, William P.; Low, Phillip A.Abstract:
The autonomic nervous system strictly maintains internal body temperature within a narrow margin of 37[degrees]C. Diseases and the drugs used to treat them can impair thermoregulation at many levels, including afferent thermoreception, the hypothalamus, descending vasomotor and sudomotor pathways, spinal intermediolateral cells, sympathetic ganglia, peripheral autonomic nerves, and the neuroeccrine junction. The brain, which is especially vulnerable to the physiologic stresses of hypothermia and hyperthermia, coordinates the vasomotor and sudomotor responses that retain or dissipate bodily heat. Numerous disorders are associated with hyperhidrosis and hypohidrosis. Some disrupt thermoregulation, and others are socially troubling, while most provide informative diagnostic clues.(C) 2007 American Academy of Neurology
Posted by Phillipa on November 16, 2009, at 18:46:01
In reply to Re: I don't sweat, posted by southernsky on November 15, 2009, at 20:58:11
I don't sweat till cooling off after excercise in extreme heat. If temp is within normal limits I just don't see a problem? Phillipa
Posted by maxime on November 17, 2009, at 12:00:37
In reply to I don't sweat, posted by linkadge on November 15, 2009, at 7:51:49
That's something you should tell a doctor. It can very dangerous not to sweat because you could overheat whilst exercising.
I wish I didn't sweat as much as I do!
This is the end of the thread.
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