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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by iforgotmypassword on August 31, 2009, at 0:20:44
they mention it has much less efficacy as an antidepressant. is it just a plain NRI like atomoxetine, or nearly? is there anything else interesting about it possibly indicating other applications for the drug? what are all of its mechanisms?
Posted by Phillipa on August 31, 2009, at 12:25:07
In reply to is desvenlafaxine (Pristiq) still an SRI?, posted by iforgotmypassword on August 31, 2009, at 0:20:44
New long acting effexor patent extender for effexor I believe. Phillipa
Posted by iforgotmypassword on August 31, 2009, at 19:03:55
In reply to Re: is desvenlafaxine (Pristiq) still an SRI? » iforgotmypassword, posted by Phillipa on August 31, 2009, at 12:25:07
it's a metabolite, but it is more selective to the NE transporter. i don't know how much SERT affinity relative to NET it has lost, if any, or if it has only lost affinity to DAT.
i want to know how much you can rely on it not being an SRI, similar to how people rely on nortrityline's selectivity, or if i can dream, desipramine's selectivity. certainly its loss of efficacy for major depression according to the always ever sacred HAM-D rating scale suggests it's possible.
Posted by yxibow on September 1, 2009, at 23:39:46
In reply to Re: is desvenlafaxine (Pristiq) still an SRI?, posted by iforgotmypassword on August 31, 2009, at 19:03:55
I'm not sure exactly -- it is probably mostly a "patent extender" for Effexor, although maybe some people respond better to it if it is "cleaner" like Lexapro theoretically is.
Effexor does have a ratio (I don't think it's an exact science) of 5HT to NE just as Cymbalta has.
It is an SNRI, so it plays a role on both transmitters. Considering how energizing and anxiety making it was for me when I took it like 15 years ago, it probably is stronger at NE, but I couldn't say. I think everyone is different and some people respond more "calmly" to stimulants.
Best I can guess.
-- tidings
This is the end of the thread.
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