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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by jms600 on August 26, 2009, at 12:21:00
Does anyone know if Anafranil / clomipramine is effective in treating severe panic disorder?? I'm going through hell at the moment with severe panic. I'm current taking Zypreza Velotab - 15mg along with 40mg buspirone, 150mg Effexor and 600mg of lithium. But the combo just ain't helping. I though the Zyprexa would help but it's really let me down. In the past i've also tried:
All of the SSRIs
Remeron
Amitriptyline
Amisulpiride
Quetiapine
Haloperidol
Stelazine
Sodium valproate
PromazineNone of the above has really helped. I can't take benzos as I've built up an addiction to them through taking to much Valium.
Would Clomipramine help severe panic? I really don't know how much more of this I can take.
Posted by jms600 on August 26, 2009, at 12:32:08
In reply to Clomipramine/Anafranil for severe panic disorder??, posted by jms600 on August 26, 2009, at 12:21:00
Posted by Brainbeard on September 1, 2009, at 12:39:47
In reply to Clomipramine/Anafranil for severe panic disorder??, posted by jms600 on August 26, 2009, at 12:21:00
> Does anyone know if Anafranil / clomipramine is effective in treating severe panic disorder??
It sure as heckfire is effective for panic. At least as effective as Paxil (http://www3.interscience.wiley.com/journal/119945101/abstract?CRETRY=1&SRETRY=0). There have even been studies suggesting that a very low dose of clomipramine can be effective in this regard, such as http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBR-3S84MBF-5&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=59731222d8903c1dbbd5b5e10327b29e, which concludes: 'These results suggest that low doses of clomipramine such as 10 mg may exert anxiolytic effects during the acute phase of treatment in highly anxious humans.'
Thing is, you are on an SRI already (Effexor). Clomipramine is as potent an SRI as sertraline (Zoloft), which is very potent. (Effexor is a very weak SRI, about four times as weak as fluvoxamine (Luvox), which is itself the weakest SSRI.) I have myself been adding a low dose of clomipramine, 10mg, to fluvoxamine (Luvox) treatment. That worked wonders for me, although it should be taken into account that fluvoxamine inhibits clomipramine's metabolism.
This is the end of the thread.
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