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Dr. Bob is Robert Hsiung, MD,
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Posted by garnet71 on May 26, 2009, at 0:43:31
Psychopharmacology
Unusual and Serious Adverse Effects of SSRIs: Recognition and ManagementJournal of Psychosocial Nursing and Mental Health Services Vol. 45 No. 3 March 2007
By Robert H. Howland, MD
EXCERPT
The selective serotonin reuptake inhibitor (SSRI) antidepressant agents fluvoxamine (Luvox®), fluoxetine (Prozac®), paroxetine (Paxil®), sertraline (Zoloft®), citalopram (Celexa®), and escitalopram (Lexapro®) are commonly used, generally well tolerated, and considered safe, especially compared with the older-generation tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs) (Howland & Thase, 2002). Because of their potent effects on serotonin reuptake, SSRIs are associated with various noxious (Masand & Gupta, 1999) and sometimes serious adverse effects (Ener, Meglathery, Van Decker, & Gallagher, 2003). In last months Psychopharmacology article, I focused on some of the most common and clinically important side effects of SSRIs. In this article, I will review more unusual and serious adverse effects associated with SSRIs.
Unusual Adverse Effects In the central nervous system,the neurotransmitters serotonin and dopamine interact with each other (Rothman &
Baumann, 2006). A secondary effect of boosting serotonin is to down-regulate, or decrease,
dopamine activity in certain regions of the brain. One area where serotonin and dopamine
interact is in the frontal lobes (Levy & Czernecki, 2006).Apathy
Extrapyramidal Symptoms
Increased Prolactin Levels
Hyponatremia
References
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Dr. Howland is Associate Professor
of Psychiatry, University of Pittsburgh
School of Medicine, Western Psychiatric
Institute and Clinic, Pittsburgh, Pennsylvania.
The author discloses that he has
no significant financial interests in any
product or class of products discussed
directly or indirectly in this activity,
including research support.
Address correspondence to Robert
H. Howland, MD, Associate Professor
of Psychiatry, University of Pittsburgh
School of Medicine, Western Psychiatric
Institute and Clinic, 3811 OHara
Street, Pittsburgh, PA 15213; e-mail:
HowlandRH@upmc.edu.
Posted by Phillipa on May 26, 2009, at 12:00:35
In reply to SSRIs and dopamine/prolactin, posted by garnet71 on May 26, 2009, at 0:43:31
Garnet what is it about the SSRI's that lead you to believe other than this study that they produce low sodium levels and milk production? Seriously I'm confused as I don't have them. Is there a study with a link? Love Phillipa
Posted by bulldog2 on May 28, 2009, at 15:39:55
In reply to Re: SSRIs and dopamine/prolactin » garnet71, posted by Phillipa on May 26, 2009, at 12:00:35
> Garnet what is it about the SSRI's that lead you to believe other than this study that they produce low sodium levels and milk production? Seriously I'm confused as I don't have them. Is there a study with a link? Love Phillipa
There are studies all over the internet if you google them...ssris elevate prolactin and in some cases this can lead to milk production...doesn't mean always...you can be sure your chronic use of luvox has lowered your hormone production
Posted by Phillipa on May 28, 2009, at 20:35:26
In reply to Re: SSRIs and dopamine/prolactin, posted by bulldog2 on May 28, 2009, at 15:39:55
Ahhh so my bioidentical hormone theraphy is a winner then. Phillipa
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