Psycho-Babble Medication Thread 893537

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clonazepam, diazepam and paradox reactions

Posted by sdb on April 30, 2009, at 3:48:54

what I've heard is especially from clonazepam and to a lesser degree diazepam can cause paradoxical reactions. clonazepam seems to give a 'blue', bad feeling where anxiety or ocd like symptoms can be increased.
So, benzo yes, but a clear diagnosis if anxiety with depression or something else combined or anxiety isolated.
Especially that low dosages of benzos can increase anxiety is not clear for me from a neurobiochemical/physiological standpoint. This is often seen in anesthesia.

Did you ever have such paradoxical reaction to clonazepam, diazepam etc. ?

 

Re: clonazepam, diazepam and paradox reactions

Posted by SLS on April 30, 2009, at 7:28:49

In reply to clonazepam, diazepam and paradox reactions, posted by sdb on April 30, 2009, at 3:48:54

> what I've heard is especially from clonazepam and to a lesser degree diazepam can cause paradoxical reactions. clonazepam seems to give a 'blue', bad feeling where anxiety or ocd like symptoms can be increased.

I wouldn't call the worsening of depression or OCD a "paradoxical" reaction in that it is not really opposite to the accepted therapeutic anxiolytic and hypnotic properties that they usually exert. A paradoxical reaction would be things like the emergence or worsening of anxiety or insomnia.

From personal experience and the accounts of others, clonazepam can indeed produce or worsen depression. It is usually a mild to moderate worsening. I have not heard of its potential to precipitate or worsen OCD. However, it seems that clonazepam has some poorly-understood serotonergic effects that indeed might be responsible for both psychiatric side effects.


- Scott

 

Re: clonazepam, diazepam and paradox reactions

Posted by Phillipa on April 30, 2009, at 9:32:11

In reply to Re: clonazepam, diazepam and paradox reactions, posted by SLS on April 30, 2009, at 7:28:49

Valium used to just relax me and now it makes me tired. Tolerance is what I was told so have lowered it and still tired and anxious at same time. Phillipa

 

Re: clonazepam, diazepam and paradox reactions

Posted by floatingbridge on April 30, 2009, at 11:05:47

In reply to Re: clonazepam, diazepam and paradox reactions, posted by Phillipa on April 30, 2009, at 9:32:11

clonazepam did seem to have a depressive feature for me. For my current anxiety go-round my pdoc had me try librium which I am not liking. I feel it causes a restless leg sort of thing that keeps me from falling asleep. Maybe some other physical aggitation or irritation, tho hard to tell since I am being treated for anxiety.

Candace

 

Re: clonazepam, diazepam and paradox reactions

Posted by sdb on April 30, 2009, at 16:22:17

In reply to Re: clonazepam, diazepam and paradox reactions, posted by floatingbridge on April 30, 2009, at 11:05:47

thanks everyone


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