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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by mav27 on December 29, 2008, at 7:41:46
Just wondering.. if this combo doesn't seem to be effecting BP or killing me what are the chances that replacing the moclobemide with parnate will be safe as well ?
Posted by SLS on December 29, 2008, at 7:55:03
In reply to prozac + moclobemide., posted by mav27 on December 29, 2008, at 7:41:46
> Just wondering.. if this combo doesn't seem to be effecting BP or killing me what are the chances that replacing the moclobemide with parnate will be safe as well ?
Almost zero.
Of all the antidepressant drugs to combine, the only real fatal reaction can come from mixing a MAOI with a SRI. This reaction is, of course, serotonin syndrome. I imagine there are a rare few who manage to take such a combination, but I haven't heard of any.
- Scott
Posted by mav27 on December 29, 2008, at 8:17:22
In reply to Re: prozac + moclobemide. » mav27, posted by SLS on December 29, 2008, at 7:55:03
> > Just wondering.. if this combo doesn't seem to be effecting BP or killing me what are the chances that replacing the moclobemide with parnate will be safe as well ?
>
> Almost zero.
>
> Of all the antidepressant drugs to combine, the only real fatal reaction can come from mixing a MAOI with a SRI. This reaction is, of course, serotonin syndrome. I imagine there are a rare few who manage to take such a combination, but I haven't heard of any.
>
>
> - ScottCool, so if youu end up in hospital with seratonin syndrome there isn't a great deal they can do about it is there to make sure you survive ?
Posted by SLS on December 29, 2008, at 19:05:58
In reply to Re: prozac + moclobemide. » SLS, posted by mav27 on December 29, 2008, at 8:17:22
> > > Just wondering.. if this combo doesn't seem to be effecting BP or killing me what are the chances that replacing the moclobemide with parnate will be safe as well ?
> >
> > Almost zero.
> >
> > Of all the antidepressant drugs to combine, the only real fatal reaction can come from mixing a MAOI with a SRI. This reaction is, of course, serotonin syndrome. I imagine there are a rare few who manage to take such a combination, but I haven't heard of any.
> >
> >
> > - Scott
>
> Cool, so if youu end up in hospital with seratonin syndrome there isn't a great deal they can do about it is there to make sure you survive ?Actually, there are protocols to treat serotonin syndrome. It is important to keep the body temperature from going to high. Hyperpyrexia is probably the symptom that most often leads to fatality. There are some drug antidotes to be used. I believe Periactin (cyproheptadine) is the drug most commonly used. It blocks the serotonin receptors so that they don't become over-stimulated.
Serotonin syndrome is treatable.
- Scott
This is the end of the thread.
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