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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by noidentity on December 16, 2008, at 7:16:34
I take 425 mg Seroquel a day... 3 x 100 and once 125. I can observe an odd pattern of reaction. About 40 minutes after a ingested a dose I begin to feel worse and dysphoric, this lasts for about 45 minutes and then I begin to feel much better, activity is possible, I become more social and do not feel as much of that unbearable tension. I am still far from healthy during this phase, but i would be much better off, if I could feel this way for the whole day. Then 40 minutes after the next dose the same pattern starts all over. Of course I experimented with all possible different forms of intake ,dosages numbers of dosages and total amount ingested, but this way of ingestion proofed to be the best.
There is one last interesting thing that I noticed, if I take a dose later than intended I can feel better for a longer time namely untill 40 minutes after the ingestion of the later taken dosage, but then the dysphoria is even worse.Did somebody experience something similiar or does somebody know something about that?
Markus
Posted by desolationrower on December 16, 2008, at 9:56:15
In reply to weird seroquel pattern, posted by noidentity on December 16, 2008, at 7:16:34
I think quetiapine has metabolite that does more of the anxiolytic/antidepressant properties...i forget its exact action though. If you have a different response to the mother drug and the metabolite your response would be expected...
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.
Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL.Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar depression, albeit by an unknown mechanism. To discover the potential mechanism for this apparently unique action, we screened quetiapine, its metabolite N-Desalkylquetiapine, and dibenzo[b,f][1,4]thiazepine-11(10-H)-one (DBTO) against a large panel of G-protein-coupled receptors, ion channels, and neurotransmitter transporters. DBTO was inactive at all tested molecular targets. N-Desalkylquetiapine had a high affinity (3.4 nM) for the histamine H(1) receptor and moderate affinities (10-100 nM) for the norepinephrine reuptake transporter (NET), the serotonin 5-HT(1A), 5-HT(1E), 5-HT(2A), 5-HT(2B), 5-HT(7) receptors, the alpha(1B)-adrenergic receptor, and the M(1), M(3), and M(5) muscarinic receptors. The compound had low affinities (100-1000 nM) for the 5-HT(1D), 5-HT(2C), 5-HT(3), 5-HT(5), 5-HT(6), alpha(1A), alpha(2A), alpha(2B), alpha(2C), H(2), M(2), M(4), and dopamine D(1), D(2), D(3), and D(4) receptors. N-Desalkylquetiapine potently inhibited human NE transporter with a K(i) of 12 nM, about 100-fold more potent than quetiapine itself. N-Desalkylquetiapine was also 10-fold more potent and more efficacious than quetiapine at the 5-HT(1A) receptor. N-Desalkylquetiapine was an antagonist at 5-HT(2A), 5-HT(2B), 5-HT(2C), alpha(1A), alpha(1D), alpha(2A), alpha(2C), H(1), M(1), M(3), and M(5) receptors. In the mouse tail suspension test, N-Desalkylquetiapine displayed potent antidepressant-like activity in VMAT2 heterozygous mice at doses as low as 0.1 mg/kg. These data strongly suggest that the antidepressant activity of quetiapine is mediated, at least in part, by its metabolite N-Desalkylquetiapine through NET inhibition and partial 5-HT(1A) agonism. Possible contributions of this metabolite to the side effects of quetiapine are discussed.
-d/r
Posted by noidentity on December 16, 2008, at 10:24:37
In reply to Re: weird seroquel pattern, posted by desolationrower on December 16, 2008, at 9:56:15
Great answer. Thank you.
Posted by desolationrower on December 16, 2008, at 23:51:16
In reply to Re: weird seroquel pattern, posted by noidentity on December 16, 2008, at 10:24:37
No problem. Welcome to pb. Let us know how things turn out.
-d/r
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