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Dr. Bob is Robert Hsiung, MD,
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Posted by Jeroen on October 27, 2008, at 12:41:44
im currently taking both this and i have unpleasant effects :(
seroquel and Abilify Interactions
BackInteractions between seroquel(quetiapine) and Abilify (aripiprazole)
quetiapine and aripiprazole (Moderate Drug-Drug)MONITOR: Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; class IA antiarrhythmics especially disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. Use of neuroleptics in combination with other neuroleptics or anticholinergic agents may increase the risk of tardive dyskinesia.
MANAGEMENT: Caution is advised when agents with anticholinergic properties are combined, particularly in the elderly and those with underlying organic brain disease, who tend to be more sensitive to the central anticholinergic effects of these drugs and in whom toxicity symptoms may be easily overlooked. Patients should be advised to notify their physician promptly if they experience potential symptoms of anticholinergic intoxication such as abdominal pain, fever, heat intolerance, blurred vision, confusion, and/or hallucinations. Ambulatory patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them. A reduction in anticholinergic dosages may be necessary if excessive adverse effects develop.
Posted by Phillipa on October 27, 2008, at 13:01:45
In reply to seroquel abilify interaction, posted by Jeroen on October 27, 2008, at 12:41:44
Jeroen you're in hospital right? So your doc is aware? Keep us informed. Love Phillipa
Posted by sam K on October 27, 2008, at 22:22:37
In reply to seroquel abilify interaction, posted by Jeroen on October 27, 2008, at 12:41:44
hey, sorry I dont like side effects at all either. I get the impression that you jump from meds to another, i dont know why. I do that too. I hope you get things straightend out! What is your diagnosis??
Posted by yxibow on October 28, 2008, at 4:13:23
In reply to seroquel abilify interaction, posted by Jeroen on October 27, 2008, at 12:41:44
> im currently taking both this and i have unpleasant effects :(
>
>
> seroquel and Abilify Interactions
> BackInteractions between seroquel(quetiapine) and Abilify (aripiprazole)
>
> quetiapine and aripiprazole (Moderate Drug-Drug)Though unpleasant, this is, as listed a moderate reaction. What it means is that added together, the anticholinergic properties of both antipsychotics can make someone experience syndromes of atropine like experiences. Notable blurred vision, urinary retention, and even psychosis at its worst among other unpleasantries. It would be the same as a bad reaction to too much Cogentin, e.g. This is what belladonna does, classically.
It depends on how much you're taking of each of course, which is why it isn't typically recommended to combine antipsychotics, at least probably certain ones because you don't know what could happen, like this, atropine effects, or QTc interval problems (heart) which are more dangerous.
But, I would speak with your doctor about this -- I'm still not quite sure why you're on both because I thought that the more potent ones would aggravate whatever tardive symptoms you might be presenting. But everyone reacts differently and sometimes I suppose you need the medication regardless of those effects to be more functional.
-- tidingsJay
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