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Dr. Bob is Robert Hsiung, MD,
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Posted by Quintal on September 7, 2008, at 12:45:47
In reply to Re: Glycine As a Primary Antipsychotic, posted by iladvocate on September 7, 2008, at 12:16:12
My doctor doesn't have any information on tianeptine. The hospital pharmacist might be able find out for him, but he'd have to call and ask. I brought some melatonin into hospital with me and she checked that it was safe to take with the other medication I was on.
Q
Posted by iladvocate on September 7, 2008, at 13:09:48
In reply to Re: Glycine As a Primary Antipsychotic » iladvocate, posted by Quintal on September 7, 2008, at 12:45:47
> My doctor doesn't have any information on tianeptine. The hospital pharmacist might be able find out for him, but he'd have to call and ask. I brought some melatonin into hospital with me and she checked that it was safe to take with the other medication I was on.
>
> QThat makes sense. As for Melatonin the prescription medication Rozerem was developed from that and has the same active ingredients and is a sleeping pill that can be taken every day without concern. If the pharmacist can do an online search and comprehensive check that's a start. Just remember you are starting a new class of antipsychotic in government study even if its outside of that not just a supplement and take it that seriously in that light and regardless of whether your psychiatrist is prescribing it do let him know what's going on as with side effects and especially any positive benefits you may obtain.
Posted by desolationrower on September 7, 2008, at 19:40:44
In reply to Re: Glycine As a Primary Antipsychotic, posted by iladvocate on September 7, 2008, at 12:16:12
There really isn't some hidden stash of doctor-only information, unless you are talking about drug rep spiels.
Posted by ILADVOCATE on September 7, 2008, at 20:40:55
In reply to Re: Glycine As a Primary Antipsychotic, posted by desolationrower on September 7, 2008, at 19:40:44
> There really isn't some hidden stash of doctor-only information, unless you are talking about drug rep spiels.
No but they could figure out drug drug interactions. I know because my psychiatrist did on his palm pilot. That includes glycine. For example the fact that it could interact with Clozaril is something I know only because my psychiatrist told me. My point in identifying these medications in development is to get the word to the public before the pharmaceutical industry uses them for promotional purposes.
Posted by desolationrower on September 7, 2008, at 21:06:23
In reply to Re: Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 7, 2008, at 20:40:55
Right, but its not his james bond palm pilot, its that there have been studies that show they don't play well together.
-D/R
Posted by ILADVOCATE on September 7, 2008, at 21:31:28
In reply to Re: Glycine As a Primary Antipsychotic, posted by desolationrower on September 7, 2008, at 21:06:23
> Right, but its not his james bond palm pilot, its that there have been studies that show they don't play well together.
> -D/RSeriously though they can look up any information online and usually in a palm pilot. They have whatever they need down there.
Posted by Zyprexa on September 7, 2008, at 23:34:33
In reply to Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 6, 2008, at 13:59:22
I've been taking glycine for 1.5 years now. It has never been able to replace the zyprexa.
Posted by ILADVOCATE on September 8, 2008, at 0:07:03
In reply to Re: Glycine not As a Primary Antipsychotic, posted by Zyprexa on September 7, 2008, at 23:34:33
> I've been taking glycine for 1.5 years now. It has never been able to replace the zyprexa.
Yes well that's what the study found. Its generally an adjunct. Be careful as with all of the atypicals Zyprexa is the most likely to cause diabetes. If you start to have weight gain or a cholesterol increase have your psychiatrist change it. Of course if you are doing okay leave it. Abilify is the least risk for diabetes but it still can cause it but they all have a risk of tardive conditions of course. I would think its helping as a supplement though. How? In what way?
Posted by Zyprexa on September 8, 2008, at 0:14:21
In reply to Re: Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 6, 2008, at 22:07:16
I find that taking Glycine is calming and stops worrying. Its not activating. I take it one heaping teaspon at a time with water or coffee, also take it every 2-3 hours as the half life is 2 hours. Often taking it about 4 times a day. I don't find it very effective, just mildly.
The best place I've found to buy it is LuckyVitamin.com, Now foods, one pound, $9. Its also called L-glycine. As my doctor told me its ok if it has the "L" in front of it. Other than that I don't know why.
I did reaseach on it and found that it affects the Canabinoid recepters in the brain. The same thing that the good portion of POT affects. The part that is antipsychotic. The THC part though is psychotic.
I did notice that it made me a little forgetfull when I started it.
Posted by Zyprexa on September 8, 2008, at 0:32:39
In reply to Re: Glycine not As a Primary Antipsychotic, posted by ILADVOCATE on September 8, 2008, at 0:07:03
I have diabetes from zyprexa, I take Metformin for it. Weight is not much of a problem, cholesterol is fine. There is no way I would go off the zyprexa, its the best med I ever took!
Abilify gave me low blood sugars. I had to eat and eat to keep my sugar high enough.
Posted by ILADVOCATE on September 8, 2008, at 0:55:12
In reply to Re: Glycine Antipsychotic, posted by Zyprexa on September 8, 2008, at 0:14:21
> I find that taking Glycine is calming and stops worrying. Its not activating. I take it one heaping teaspon at a time with water or coffee, also take it every 2-3 hours as the half life is 2 hours. Often taking it about 4 times a day. I don't find it very effective, just mildly.
>
> The best place I've found to buy it is LuckyVitamin.com, Now foods, one pound, $9. Its also called L-glycine. As my doctor told me its ok if it has the "L" in front of it. Other than that I don't know why.
>
> I did reaseach on it and found that it affects the Canabinoid recepters in the brain. The same thing that the good portion of POT affects. The part that is antipsychotic. The THC part though is psychotic.
>
> I did notice that it made me a little forgetfull when I started it.So in other words you find it has a short half life too? The same as I found. That's important because the official study gives it once a day.
Probably better to take it directly with water not coffee as it can be mixed into water and then taken in pure form. Anything else might make it work less. And caffeine underminds psychiatric medications of many kinds. Something to think about. I don't believe it affects THC receptors. The glutamate antagonists are officially called the NMDA receptor modulators. They work on a different area of the brain. Look at the link to Dr. Javitt's study for more information. That should tell you. I did summarize it for Wikipedia but that's in brief. And yes the glutamate antagonists are being studied for anxiety too so to get an anti-anxiety effect is not surprising.
Posted by ILADVOCATE on September 8, 2008, at 0:59:07
In reply to Re: Glycine not As a Primary Antipsychotic, posted by Zyprexa on September 8, 2008, at 0:32:39
> I have diabetes from zyprexa, I take Metformin for it. Weight is not much of a problem, cholesterol is fine. There is no way I would go off the zyprexa, its the best med I ever took!
>
> Abilify gave me low blood sugars. I had to eat and eat to keep my sugar high enough.
I would never go against an informed consumers decision but just be careful as many people on Zyprexa did develop insulin dependent diabetes. And it has a strong mood stabilization effect so it was used much until it was found that the drug company Eli Lilly gave fraudelent results to psychiatrists about the high rate of diabetes that it could create. Now many psychiatrists are not using it as much. However, it has been shown to highly effective. Just be careful with your diet and blood sugar.
Posted by desolationrower on September 8, 2008, at 1:24:45
In reply to Re: Glycine not As a Primary Antipsychotic, posted by ILADVOCATE on September 8, 2008, at 0:59:07
BTW, glycine is not a glutamate antagonist, it is a co-agonist.
-D/R
Posted by ILADVOCATE on September 8, 2008, at 1:49:16
In reply to Re: Glycine not As a Primary Antipsychotic, posted by desolationrower on September 8, 2008, at 1:24:45
> BTW, glycine is not a glutamate antagonist, it is a co-agonist.
> -D/R
Yes I try to keep the terminology accurate. My psychiatrist had stated to refer to them as "NMDA receptor modulators". I just wasn't sure people would understand that term but that is the correct one. Thanks for letting me know.
Posted by Jamie R on September 8, 2008, at 5:32:57
In reply to Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 6, 2008, at 13:59:22
Grape seed extract is a good co-agonist to glycine.
Posted by ILADVOCATE on September 8, 2008, at 5:44:13
In reply to Re: Glycine As a Primary Antipsychotic, posted by Jamie R on September 8, 2008, at 5:32:57
> Grape seed extract is a good co-agonist to glycine.
I'd need more information on that and why.
Posted by Larry Hoover on September 8, 2008, at 7:40:48
In reply to Re: Glycine Antipsychotic, posted by Zyprexa on September 8, 2008, at 0:14:21
> The best place I've found to buy it is LuckyVitamin.com, Now foods, one pound, $9. Its also called L-glycine. As my doctor told me its ok if it has the "L" in front of it. Other than that I don't know why.
Glycine is unique among the amino acids in its not being chiral. Therefore, the D-/L- designation is not applied to it. Glycine is officially just glycine. For all the other amino acids, the L- enantiomer is the natural one.
Lar
Posted by Zyprexa on September 8, 2008, at 16:52:40
In reply to Re: Glycine Antipsychotic, posted by ILADVOCATE on September 8, 2008, at 0:55:12
I didn't say it affected THC, I said it affects cannibanoid recepters. I also find it workes better with coffee.
Posted by Zyprexa on September 8, 2008, at 16:55:40
In reply to Re: Glycine not As a Primary Antipsychotic, posted by ILADVOCATE on September 8, 2008, at 0:59:07
I've noticed that zyprexa dose size is the determining factor as how much the blood suger is going up. My blood sure results have not gotten worse over the years. And if I stop the zyprexa, blood suger is normal again.
Posted by Zyprexa on September 8, 2008, at 16:58:54
In reply to Re: Glycine Antipsychotic » Zyprexa, posted by Larry Hoover on September 8, 2008, at 7:40:48
What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
Posted by ILADVOCATE on September 8, 2008, at 17:19:59
In reply to Re: Glycine Antipsychotic » Larry Hoover, posted by Zyprexa on September 8, 2008, at 16:58:54
> What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
Its part of the full name of the amino acid. Any pure form of glycine such as:
http://www.vitalnutrients.net/vnestore/detail.asp?product_id=VNGLY
Which I take is fine.
Posted by ILADVOCATE on September 8, 2008, at 17:25:27
In reply to Re: Glycine not As a Primary Antipsychotic » ILADVOCATE, posted by Zyprexa on September 8, 2008, at 16:55:40
> I've noticed that zyprexa dose size is the determining factor as how much the blood suger is going up. My blood sure results have not gotten worse over the years. And if I stop the zyprexa, blood suger is normal again.
Well then it hasn't worsened into type 2 diabetes. But that doesn't mean it couldn't and Zyprexa is the clinically proven worst offender for that. You are right to stay on what is working for you but keep updating with what is coming out. There are a couple that might be out soon. They are the standard dopamine based ones but they are related to Abilify and would have less of a risk than Zyprexa. Either way its good to keep updated. Check this link and bookmark it as it updates itself:
http://www.psychmeds123.info/
Posted by Larry Hoover on September 8, 2008, at 17:32:38
In reply to Re: Glycine Antipsychotic » Larry Hoover, posted by Zyprexa on September 8, 2008, at 16:58:54
> What does the "L" mean? Is L-Glycine the same as Glycine? Or does L mean Natural?/Organic?
The L stands for levo (left), whereas D stands for dextro (right). They describe the twisting of light by crystals of the pure substance. I know that doesn't mean much to anyone but a chemist.....
There is no L-glycine. It's all just glycine. And it doesn't twist light passing through its crystals.
Some molecules have structures that differ in "handedness", like matching right and left gloves. One example from among the amino acids is phenylalanine. You can buy DLPA (D-,L-phenylalanine) which is a mixture of the two structures. It's all phenylalanine, but half is left-twisting, and half is right-twisting. You can tell it's man-made, because it is such a mixture.
In nature, virtually without exception, only the L-twisting amino acids exist, because the twisting matters to protein structure. So, natural source phenylalanine would be pure L-phenylalanine. However, the converse is not necessarily true; pure L-phenylalanine can be man-made.
Lar
Posted by bleauberry on September 8, 2008, at 21:47:17
In reply to Glycine As a Primary Antipsychotic, posted by ILADVOCATE on September 6, 2008, at 13:59:22
Jereon needs to read this thread.
My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
Posted by ILADVOCATE on September 8, 2008, at 21:53:04
In reply to Re: Glycine as Antipsychotic - JEREON !!!!!, posted by bleauberry on September 8, 2008, at 21:47:17
> Jereon needs to read this thread.
>
> My psych doc also spoke very highly of glycine for psychotic symptoms and anxiety symptoms.
Then he must be well informed. Is he a psychopharmocologist? Where did he get this information from? I thought mine was the only one using it outside of study? I'd be interested to know.
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