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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Ramin on March 26, 2008, at 17:45:51
Ok, I'm a bit confused. If a agonism of 5HT1A receptors is a primary mechanism that helps with symptoms of depression and anxiety, then how is it that seroquel doesn't have some depression exacerbating properties.
After all, in addition to antagonizing various receptors, it also antagonizes 5HT1A.
Could someone please explain this all to me?
I got really confused after seeing this response to a different thread:
http://www.dr-bob.org/babble/20080221/msgs/813925.html
Posted by undopaminergic on March 27, 2008, at 18:04:57
In reply to Seroquel is used to help with depression?, posted by Ramin on March 26, 2008, at 17:45:51
> Ok, I'm a bit confused. If a agonism of 5HT1A receptors is a primary mechanism that helps with symptoms of depression and anxiety, then how is it that seroquel doesn't have some depression exacerbating properties.
>
> After all, in addition to antagonizing various receptors, it also antagonizes 5HT1A.
It is also reported to be a partial agonist at the receptor, so its net effect (on 5-HT1A) may depend on concentrations of endogenous serotonin.> Could someone please explain this all to me?
>Stimulation of 5-HT1A enhances dopamine (DA) release primarily in the prefrontal cortex (PFC). Excessive or insufficient DA release in the PFC disrupts working memory. Injury to the PFC DA system appears to produce locomotor hyperactivity, while microinjections of DA agonists into the intact PFC reduce the locomotor response to novelty or psychostimulant drugs. Rats self-administer cocaine but not amphetamine into the PFC. There are more facts to look up about PFC DA.
Seroquel also affects many other receptors, and the consequences need to be factored into your model of its pharmacology. The most consistently reported result of its ingestion seems to be a sedative/hypnotic effect.
Posted by Dopamine123 on March 30, 2008, at 21:43:12
In reply to Re: Seroquel is used to help with depression?, posted by undopaminergic on March 27, 2008, at 18:04:57
Well I think it is complicated.
http://www.med.nyu.edu/psych/psychiatrist/depression/slides/sld035.html
>The selective activation of postsynaptic 5-HT1A receptors by buspirone in the presence of the presynaptic 5-HT1A antagonist pindolol appears to induce a rapid and robust antidepressant response.Activation of postsynaptic 5-ht1a receptors has antidepressant properties. Antagonism of 5-ht1a autoreceptors can increase serotonin in the synapse and actually lead to increased activation of postsynaptic 5-ht1a receptors. So a drug like pindolol is a 5-ht1a antagonist, but it increases serotonin in the synapse because it blocks the autoreceptor.
See the picture at this website (buspirone is a 5-ht1a agonist while pindolol is an antagonist):
http://www.med.nyu.edu/psych/psychiatrist/depression/slides/sld036.htmlIts confusing, but in the end seroquel probably leads to an increased activation of postsynaptic 5-ht1a receptors.
Posted by Jeroen on April 6, 2008, at 15:48:28
In reply to Re: Seroquel is used to help with depression?, posted by Dopamine123 on March 30, 2008, at 21:43:12
hi, the first time seroquel worked very good for depression and psychosis, but it got pooped out after 2 months, and never worked anymore
so now i am on seroquel for psychosis, and the depression is worse, also if i go higher i feel more depressed and get pannick attacks
so basically Maxime from this board her depression was also worse if i remind, but you might react different to it, just give it a 3 week trial
if you feel better then stick to it
good luck with your health!
This is the end of the thread.
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