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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by qbsbrown on November 1, 2007, at 18:18:48
Or is it closer to 3-1. I know the max of Lyrica is 600mg, and Neurontin is around 3600-4800.
I appreciate you all.
Brian
Posted by King of Nothing on November 1, 2007, at 18:59:27
In reply to Is there conversion of Lyrica and Neurontin? 4-1?, posted by qbsbrown on November 1, 2007, at 18:18:48
> Or is it closer to 3-1. I know the max of Lyrica is 600mg, and Neurontin is around 3600-4800.
>
> I appreciate you all.
>
> Brian600 is not the max for Lyrica, i have read of Docs going as high as 1200mgs. a day.
Posted by qbsbrown on November 1, 2007, at 19:02:11
In reply to Re: Is there conversion of Lyrica and Neurontin? 4-1? » qbsbrown, posted by King of Nothing on November 1, 2007, at 18:59:27
It's just listed as 600mg being the max.
My PDOC says can go to 900mg.
I've just been takinng 225mg at night. I wonder if i can just jump in and take 3600mg of the neurontin.
Posted by King of Nothing on November 1, 2007, at 19:05:43
In reply to Re: Is there conversion of Lyrica and Neurontin? 4-1?, posted by qbsbrown on November 1, 2007, at 19:02:11
> It's just listed as 600mg being the max.
>
> My PDOC says can go to 900mg.
>
> I've just been takinng 225mg at night. I wonder if i can just jump in and take 3600mg of the neurontin.Why do you need the neurontin? Why not just go higher on the Lyrica?
Posted by Phillipa on November 1, 2007, at 23:13:42
In reply to Re: Is there conversion of Lyrica and Neurontin? 4-1? » qbsbrown, posted by King of Nothing on November 1, 2007, at 19:05:43
I hear they are about the same. Hey what about weight gain and lyrica? Love Phillipa
Posted by qbsbrown on November 2, 2007, at 0:39:26
In reply to Re: Is there conversion of Lyrica and Neurontin? 4-1? » King of Nothing, posted by Phillipa on November 1, 2007, at 23:13:42
> I hear they are about the same. Hey what about weight gain and lyrica? Love Phillipa
Nope, no weight problems with the Lyrica for me. After gaining 50 pounds on Depakote, Zyprexa, and Lithium, I'll happily take the Neurontin.FYI, my sleep on Lyrica is great. Very deep and refreshing, which i know is a big prob for us bipolars.
Posted by Larry Hoover on November 2, 2007, at 8:14:49
In reply to Is there conversion of Lyrica and Neurontin? 4-1?, posted by qbsbrown on November 1, 2007, at 18:18:48
> Or is it closer to 3-1. I know the max of Lyrica is 600mg, and Neurontin is around 3600-4800.
>
> I appreciate you all.
>
> BrianNo, there is no ratio that is useful. The problem is that Neurontin (gabapentin) does not follow a linear dose/uptake curve; the more Neurontin you take, the lesser the proportion making it into the bloodstream. One of the early selling points of Lyrica over Neurontin was its linear dose-uptake curve. Doubling the dose meant doubling the blood concentration, unlike Neurontin.
Based on the clinical trials for Neurontin, if you only took 900 mg/day, you'd get 60% of it, i.e. 540 mg. At 3600 mg/day, the true uptake is about 33%, i.e. only 1200 mg makes it into the blood. 4 times the dose, but only a little over double the uptake. 4800 mg/day has 27% uptake, so that's 1296. More than five times the 900 mg dose, but not even 2 1/2 times the uptake.
What this suggests is that the uptake mechanism is saturable, i.e. there is a maximum that can be taken up by the body, beyond which no increase in dose will have an effect.
Bottom line.....don't make dose comparisons. Compare response.
Lar
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