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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Jimmyboy on January 19, 2007, at 18:08:49
This says Royal Jelly increases GDNF by a major 40% . There were threads over at Avant forums ( sp?) - where people tried this out with a certain kind ..
Biosci Biotechnol Biochem. 2005 Apr ;69:800-5 15849420
"Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain."
[My paper] Manabu Hashimoto , Masafumi Kanda , Kumiko Ikeno , Yoshirou Hayashi , Tadashi Nakamura , Yoshinobu Ogawa , Hidefumi Fukumitsu , Hiroshi Nomoto , Shoei FurukawaRoyal jelly (RJ) is known to have a variety of biological activities toward various types of cells and tissues of animal models, but nothing is known about its effect on brain functions. Hence, we examined the effect of oral administration of RJ on the mRNA expression of various neurotrophic factors, their receptors, and neural cell markers in the mouse brain. Our results revealed that RJ selectively facilitates the mRNA expression of glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor acting in the brain, and neurofilament H, a specific marker predominantly found in neuronal axons, in the adult mouse hippocampus. These observations suggest that RJ shows neurotrophic effects on the mature brain via stimulation of GDNF production, and that enhanced expression of neurofilament H mRNA is involved in events subsequently caused by GDNF. RJ may play neurotrophic and/or neuroprotective roles in the adult brain through GDNF
Posted by linkadge on January 19, 2007, at 19:50:34
In reply to GDNF - interesting article, posted by Jimmyboy on January 19, 2007, at 18:08:49
Yeah, interesting. Supposedly injections of GDNF in certain brain areas can restore movement in parkinsons disease.
Linkadge
Posted by linkadge on January 19, 2007, at 20:08:53
In reply to Re: GDNF - interesting article, posted by linkadge on January 19, 2007, at 19:50:34
Melatonin also supposedly increases GDNF, as well as BCL-2, and I think BDNF.
Heres one for you. Lithium has been shown to increase GFAP. But, is this a good thing?
http://www.medscape.com/medline/abstract/7931315Linkadge
Posted by Jimmyboy on January 20, 2007, at 1:50:14
In reply to Re: GDNF - interesting article, posted by linkadge on January 19, 2007, at 20:08:53
Hey Linkadge, that link is not working, can you repost it?
Also.. we seem to be on the same page when it comes to believing the real thing to consider is the differant neurotrophic factors ( BDNF, NGF, GDNF, etc , etc.) I really think it would be good if we could start a thread or area where we consolidate all the studies and data so we can see it all as the big picture as opposed to reading a study here and a study there , etc.I personally think that is one of the most the important underlying issues with depression. What do you think ?
JB
Posted by linkadge on January 20, 2007, at 8:06:13
In reply to Can you repost that link? » linkadge, posted by Jimmyboy on January 20, 2007, at 1:50:14
The link should work, (but you may need a registration to medscape - is free, might be worthwile)
I do think that the neurotrophin hypothesis holds more water than the monoamine hypothesis.
There is only one thing that concerns me (personally) about ingesting substances exclusively for their effects on brain neurotrophins. (The archives are probably full of my search for neurotrophic agents)
Sometimes neurotrophins are upregulated in reponse to a neuronal injury. For instance, epilepsy, after a seizure, levels of certain neurotrophins are very high. As well, some authors have shown that after traumatic brain injury, neurotrophin levels are very high - I suppose almost like a injury response system designed to further protect and aid in repair.
Indeed ECT has the ability to increase BDNF much more than antidepressant treatment. I remember reading that ECT increases BDNF by 120%, wherase antidepressants only by perhaps 20%http://biopsychiatry.com/bdnf-antidep.htm
Also in this study, the antidepressants did not increase BDNF in the hippocampus, an area supposedly responsable for the AD effect.
Anyhow, my point was that just because an agent increases BDNF doesn't mean that it is a good thing. It may be infact that the agent is causing brain dammage, and that BDNF is simply a response.
Now, I don't think that things like royal jelly or turmeric are by any means causing brain dammage, but when it comes to agents like ECT I wonder. Could this just be a response to brain injury, just like with other brain injury?
Linkadge
This is the end of the thread.
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