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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by saturn on November 27, 2006, at 15:06:53
spelling. Please allow me to list them:
1. I realize it doesn't compare to benzos but is it even modestly effective for GAD or SP?
2. Re: dopamine binding actions. The prescribing info mentions this but what is the relative likelihood of EPS?
3. and what's up with the weird spelling (captial S)? Ok now I'm getting off topic. Sorry.
Peace.
Posted by Quintal on November 27, 2006, at 17:09:17
In reply to Questions regarding BuSpar efficacy DA binding and, posted by saturn on November 27, 2006, at 15:06:53
>1. I realize it doesn't compare to benzos but is it even modestly effective for GAD or SP?
Not for me! But as ever, milage varies......
Q
Posted by JerryPharmStudent on November 28, 2006, at 2:55:12
In reply to Questions regarding BuSpar efficacy DA binding and, posted by saturn on November 27, 2006, at 15:06:53
> spelling. Please allow me to list them:
>
> 1. I realize it doesn't compare to benzos but is it even modestly effective for GAD or SP?
>
> 2. Re: dopamine binding actions. The prescribing info mentions this but what is the relative likelihood of EPS?
>
> 3. and what's up with the weird spelling (captial S)? Ok now I'm getting off topic. Sorry.
>
> Peace.Works wonders for my anxiety - and I rarely respond to anything. Felt better within 5 days. Have no problems with EPS. I think it's a great med and underused.
Posted by med_empowered on November 28, 2006, at 4:18:21
In reply to Re: Questions regarding BuSpar efficacy DA binding and » saturn, posted by JerryPharmStudent on November 28, 2006, at 2:55:12
my own experience was so-so. 30mgs ok, then not helpful at all; 45mgs...awful. Somehow, it worsened my anxiety. Maybe akathisia?
Anyway...just from what I've read, it seems that BuSpar can cause EPS now and then, and there are a couple cases of buspar-induced tardive dyskinesia, but its not considered a major side effect. I read somewhere that BuSpar works best added to an antidepressant.
Posted by hgi698 on December 1, 2006, at 16:47:11
In reply to Questions regarding BuSpar efficacy DA binding and, posted by saturn on November 27, 2006, at 15:06:53
"Buspirone is a partial agonist at serotonin 5-HT1A receptors (17). It also acts as an antagonist at dopamine D2 receptors, but its affinity for these receptors is 16-fold weaker than its affinity for 5-HT1A receptors (18)."
Thus, the dose of buspirone to block the D2 receptor would have to be 16 fold higher than the dose needed for agonism of the 5-ht1a receptor. Since it is relatively selective I wouldn't worry about it. There's indication that buspirone can be pro-sexual too which would indicate and increase in dopaminergic neurotransmission.
This is the end of the thread.
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