Psycho-Babble Medication Thread 681939

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Amisulpride stopped--bradycardia, sedation

Posted by psychobot5000 on August 31, 2006, at 23:56:44

Hi,

On or around day eight of my trial with amisulpride, which had offered a modest benefit for my mood, I stopped the medication, on an associate's medical advice, because of bradycardia, and combination with another -potentially- heart-dangerous med.

But my final feeling on it, was that it improved my mood, just a little, and perhaps my mental functioning (I suffer from either depressive pseudodementia, or innattentive ADD--it's all in how you interpret the symptoms). But unfortunately, the med sedated me considerably, and I can't say it did anything for my motivation.

It's possible I could've built up enough tolerance to the sedation to get by, especially if the dose were lowered to 25mg, but the slowed heart rate seemed to make attempting that a bad idea.

I'm trying ropinirole now, and hoping for positive effects. Ironically, the main side-effect so far (day 2) is sedation. Oh, well.

If this doesn't work out, I'm considering pindolol--as augmentation for tianeptine. Who knows how that would work out, but if pindolol works through 5-HT 1a antagonism, then I don't believe their mechanisms of action would be in conflict (?).

Well, if the Requip sedation doesn't pass, then I may just see.

P-bot

 

Re: Amisulpride stopped--bradycardia, sedation » psychobot5000

Posted by Declan on September 1, 2006, at 2:40:55

In reply to Amisulpride stopped--bradycardia, sedation, posted by psychobot5000 on August 31, 2006, at 23:56:44

Have you considered rhodiola?

Do you sleep well?

 

Re: Amisulpride stopped--bradycardia, sedation

Posted by linkadge on September 1, 2006, at 6:31:21

In reply to Re: Amisulpride stopped--bradycardia, sedation » psychobot5000, posted by Declan on September 1, 2006, at 2:40:55

Pindolol though is a 5-ht1a 'autoreceptor' antagonist. Most psychiatric drugs work on the post synaptic receptors, but pindolol is thought to enhance serotonin release via blocking the inhibitory 5-ht1a autoreceptors.

So, it would enhance 5-ht release but the tianeptine would acellerate its reuptake. So, not sure what the end effect would be.


Linkadge

 

Re: Amisulpride stopped--bradycardia, sedation

Posted by psychobot5000 on September 1, 2006, at 10:03:32

In reply to Re: Amisulpride stopped--bradycardia, sedation » psychobot5000, posted by Declan on September 1, 2006, at 2:40:55

> Have you considered rhodiola?
>
> Do you sleep well?

I'm afraid I don't sleep well--it's a chronic problem.

I have rarely heard of rhodiola before...just looking it up, and I have little idea what its mechanisms of action are. Do you know if there are any good studies showing its efficacy? It sounds pretty good, though a broad range of effects are claimed.

 

Re: Amisulpride stopped--bradycardia, sedation

Posted by Declan on September 7, 2006, at 3:41:31

In reply to Re: Amisulpride stopped--bradycardia, sedation, posted by psychobot5000 on September 1, 2006, at 10:03:32

Rhodiola's definately effecacious at something. But it might not promote deep sleep. Afraid I don't know of any studies.

 

Re: Rhodiola--thanks for the tip --nm

Posted by psychobot5000 on September 7, 2006, at 20:08:24

In reply to Re: Amisulpride stopped--bradycardia, sedation, posted by Declan on September 7, 2006, at 3:41:31

nm


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