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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Tom Twilight on September 6, 2006, at 2:05:32
I tried Adrafinil in the past with quite good results.
I'd love to combine something with Nardil, to counteract the lazyness and sleepiness!Unfortunatly I've heard of at least one hypotensive crisis from this combo!
Does anyone have any comments?
Posted by SLS on September 6, 2006, at 4:34:23
In reply to Nardil with Adrafinil?, posted by Tom Twilight on September 6, 2006, at 2:05:32
> I tried Adrafinil in the past with quite good results.
> I'd love to combine something with Nardil, to counteract the lazyness and sleepiness!
>
> Unfortunatly I've heard of at least one hypotensive crisis from this combo!
>
> Does anyone have any comments?
Did you mean hypertensive?I'm sad to hear that there have been any incidents. I would have thought that the combination would be safe. To my knowledge, Provigil does not act at the NE synapse. Early claims that it was a NE alpha-1 agonist were determined to be in error. Perhaps there has been more recent work to demonstrate NE snyaptic activity. I don't know. It really doesn't matter, though. The induction of hypertensive events with MAOIs are not completely understood, so we are sometimes relegated to judge safety simply by what we see clinically. If one event with Provigil is reported, it goes on the list.
Where did you hear of the Provigil-induced hypertensive event?
- Scott
Posted by Tom Twilight on September 6, 2006, at 7:53:19
In reply to Re: Nardil with Adrafinil?, posted by SLS on September 6, 2006, at 4:34:23
> > I'd love to combine something with Nardil, to counteract the lazyness and sleepiness!
Hey ScottI'm sorry I caused a lot of confusion!
Firstly I'm worried about a Hypertensive reaction combining Nardil and Adrafinil.
My mistake!Secondly, to the best of my knowlage, I don't think there's any problem combining Provigil with MAOIs.
The problem is Provigil does nothing for me but make me slightly anxious :(
I'm of the opinion that there's more of a difference between Provigil(Modafinil and Adrafinil than is generally reallised!
Therefore Adrafinil might cause problems, were Provigil might not.
Posted by SLS on September 6, 2006, at 8:15:08
In reply to Nardil with Adrafinil-Confusion!, posted by Tom Twilight on September 6, 2006, at 7:53:19
Sorry for the confusion.
Even adrafinil is not a NE alpha-1 agonist. A friend of mine had the opportunity to speak to the developer of the molecule at a symposium several years ago. Still, I couldn't guarantee the safety of the combination. I had wanted to combine Provigil with Nardil or Parnate. Unfortunately, I reacted badly to Provigil. It exacerbated my depression.
- Scott
Posted by Oppycat on September 6, 2006, at 10:17:29
In reply to Re: Nardil with Adrafinil-Confusion!, posted by SLS on September 6, 2006, at 8:15:08
I took Provigil(200 mg) with Nardil several days ago just before abandoning my Nardil trial. Although I didn't have a hypertensive crisis, I did have increased anxiety and, perhaps, more depression.
I also took Adrafinil with Parnate about 6 years ago with no ill effects, but no obvious benefit either.
I find it interesting that Provigil increased my anxiety when Adderall at 40mg daily doesn't bother me at all.
Michael
Posted by SLS on September 6, 2006, at 12:16:42
In reply to Re: Nardil with Adrafinil-Confusion!, posted by Oppycat on September 6, 2006, at 10:17:29
> I find it interesting that Provigil increased my anxiety when Adderall at 40mg daily doesn't bother me at all.
That's consistent with what other people reported here on Psycho-Babble a few years ago.
- Scott
Posted by Tom Twilight on September 7, 2006, at 1:59:54
In reply to Re: Nardil with Adrafinil-Confusion!, posted by SLS on September 6, 2006, at 12:16:42
Didn't like Provigil at all
Just made me Jittery!
Posted by willyee on September 7, 2006, at 12:04:02
In reply to Re: Nardil with Adrafinil-Confusion!, posted by Tom Twilight on September 7, 2006, at 1:59:54
> Didn't like Provigil at all
>
> Just made me Jittery!Added it to parnate,paid tons too as i did this at the drugs peak of arrival when its cost was more outrageous than it is now.
I also felt a darkening cloud,parnates effect did little to nothing,and i had a strong stimulant reaction of the kind where your just up,not a racing and crash,rather i was just up i almost lost my job at the time due to it.
This is the end of the thread.
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