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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by terrysquier on July 23, 2006, at 13:07:31
Hi. I'm new to this forum, but after browsing for quite a while I've found out some useful information. I've been through many depression med forums and seen different things about tianeptine compared to ssri's. Nowhere have I seen anything about whether using both of them in combination. So that's my question. I'm on Paxil and have been for many years. I started on Effexor last January, 75 mg per day, as an adjunct. I know that Paxil and Effexor work entirely differently from tianeptine, but has anyone had any experiences with adding tianeptine to the Paxil and Effexor or know of any research regarding it. I'm impressed with the studies about tianeptine and would like to use it. I've been on Paxil so long that I really don't think it works anymore, but it is such a hard med to get off from, that I just keep on taking it.
So any ideas, folks, would be appreciated.
I also have
access to reboxetine, which I understand is primarly a SNRI. When I
took it before, it seemed to bother my eyesight but I was taking the
recommended dose of 8 mg a day. I'm thinking about cutting back on the
dosage to maybe 4 mg a day and see what that does. I'm thinking more
in terms of increasing the chemicals in my body that will stimulate my
motivation and "get-r-done" attitude, which I understand that
reboxetine would be great for. I know that Effexor also blocks
reuptake of norephedrine but the dose I take is small and maybe
reboxetine would be a plus.Let me say that I'm not much of a believer in OTC health foods and
remedies. I've tried them all and they just don't have an effect on
me. I'd rather stick with the prescription meds that I know cause
changes in my thinking than messing everything up by adding something
like DMAE or DHEA or ALCAR that may interfere with the actions of the
prescript meds.So this is another question for everyone to ponder and think about.
Most of you are certainly more experienced and knowledgable about these
subjects than I am.Terry
Posted by linkadge on July 23, 2006, at 16:07:08
In reply to Med combo question, posted by terrysquier on July 23, 2006, at 13:07:31
Tianeptine with effexor or paxil, might reverse some of the serotonin uptake inbition of either drug. This might leave you with a more ballanced ratio of serotonin to norepinephrine.
OHOH this could be achieved by lowering paxil and or adding reboxetine.
I think that many of the neuroprotective effects of tianeptine depend on the accelleration of serotonin uptake, so I don't know if you'd attain them while taking it with a SSRI.
I've heard of a few people combining the two but I havn't heard of much striking effect.
You might be able to fine tune things with just paxil and reboxetine, but you may have already tried that.
Its too bad you've turned completely off alternatives. Industry can work to discredit some of these products which have potential.
Omega-3 can probably acurately boast about twice the brain health beneiftis as tianeptine. High EPA preparations have some documented antidepressant effect.
http://biopsychiatry.com/eicosapentaenoicacid.htm
Linkadge
Posted by SLS on July 23, 2006, at 16:22:58
In reply to Re: Med combo question, posted by linkadge on July 23, 2006, at 16:07:08
> Tianeptine with effexor or paxil, might reverse some of the serotonin uptake inbition of either drug. This might leave you with a more ballanced ratio of serotonin to norepinephrine.
>
> OHOH this could be achieved by lowering paxil and or adding reboxetine.
>
> I think that many of the neuroprotective effects of tianeptine depend on the accelleration of serotonin uptake, so I don't know if you'd attain them while taking it with a SSRI.
>
> I've heard of a few people combining the two but I havn't heard of much striking effect.
>
> You might be able to fine tune things with just paxil and reboxetine, but you may have already tried that.
>
> Its too bad you've turned completely off alternatives. Industry can work to discredit some of these products which have potential.
>
> Omega-3 can probably acurately boast about twice the brain health beneiftis as tianeptine. High EPA preparations have some documented antidepressant effect.
>
> http://biopsychiatry.com/eicosapentaenoicacid.htm
Is the reduced neuronal phospholipid turnover an indicator of neurotrophic activity? I would surmise that this is possible given the reduction in the sizes of the ventricles. At the very least, it should represent an enhancement in membrane integrity.What is the niacin thing all about?
- Scott
Posted by Phillipa on July 24, 2006, at 0:24:05
In reply to Re: Med combo question » linkadge, posted by SLS on July 23, 2006, at 16:22:58
Lar used to recommend not nicin but niacinamide. No flushing and hot flashes with that. Love Phillipa
Posted by linkadge on July 24, 2006, at 20:30:39
In reply to Re: Med combo question » linkadge, posted by SLS on July 23, 2006, at 16:22:58
Not sure, I know that niacin interacts with phospholipids in some way.
Reduced phospholipid turnover? Not sure, perhaps indicitive of improved phospholipid ballance.
Really not too sure.
Linkadge
This is the end of the thread.
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