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Dr. Bob is Robert Hsiung, MD,
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Posted by sdb on October 8, 2005, at 17:34:25
The half-life of n-demethyl-metabolites of common Benzos (Valium, Tranxene) are according to literature from 50-68 hours to almost 200 hours or more.
Does somebody know more on that (dependent on liver-transformation cytochromes, age, gen-polymorphism)?
These big differences in pharmakodynamics would lead to totally different dosage rythm and dosage amount. I really dont like the pharmacology compendiums in which docs look and do exactly what in the book is written (once daily this dosage, blabla).
Its much more complicated from person to person it seems most docs and pharmacologists did not learn much (differences in gastrointestinal absorption (protein), different spectrum of cytochromes, differences on receptors, polymorphism and so on. Its much more complicated.
Posted by Phillipa on October 8, 2005, at 18:24:30
In reply to half-life of N-Demethyl-Metabolites, posted by sdb on October 8, 2005, at 17:34:25
Valium lasts 200hrs. Yikes! Fondly, Phillipa
This is the end of the thread.
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