Psycho-Babble Medication Thread 541013

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Remeron for post-stroke depression

Posted by ed_uk on August 13, 2005, at 9:20:19

Mirtazapine for prevention and treatment of post-stroke depression in patients with
acute stroke?

Source J Clin Psychiatry. 2004 Dec;65(12):1619-23

According to a report in the Journal of Clinical Psychiatry, mirtazapine, initiated on the first day after acute
ischaemic stroke is effective in preventing the onset of depression.
The study aimed to examine whether prophylactic treatment with the antidepressant mirtazapine in patients
with acute stroke given from day 1 after the incidence prevents post-stroke depression.
The study involved 70 patients with ischaemic stroke who received either 30 mg mirtazapine or no
antidepressant medication from day 1 after the stroke in an open, randomised study design. Data were
collected for a period of 17 months. Patients were re-examined on days 7, 44, 90, 180, 270, and 360 using
neurologic, functional, and depression rating scales. Those post-stroke patients who developed depression
(DSM-IV criteria) but had been randomly assigned to the nontreatment group were given the antidepressant
mirtazapine after the diagnosis of depression had been established.
According to the researchers, 40% (14/35) of the nontreated patients and 5.7% (2/35) of the patients who
were treated with mirtazapine developed post-stroke depression. Fifteen of these remitted after initiation of
treatment with mirtazapine. The authors estimate that mirtazapine use will prevent 34 cases of depression for
every 100 stroke patients treated.

Re: Remeron for post-stroke depression » ed_uk

Posted by Nixon on August 13, 2005, at 20:38:08

In reply to Remeron for post-stroke depression, posted by ed_uk on August 13, 2005, at 9:20:19

> Mirtazapine for prevention and treatment of post-stroke depression in patients with
> acute stroke?
>
> Source J Clin Psychiatry. 2004 Dec;65(12):1619-23
>
> According to a report in the Journal of Clinical Psychiatry, mirtazapine, initiated on the first day after acute
> ischaemic stroke is effective in preventing the onset of depression.
> The study aimed to examine whether prophylactic treatment with the antidepressant mirtazapine in patients
> with acute stroke given from day 1 after the incidence prevents post-stroke depression.
> The study involved 70 patients with ischaemic stroke who received either 30 mg mirtazapine or no
> antidepressant medication from day 1 after the stroke in an open, randomised study design. Data were
> collected for a period of 17 months. Patients were re-examined on days 7, 44, 90, 180, 270, and 360 using
> neurologic, functional, and depression rating scales. Those post-stroke patients who developed depression
> (DSM-IV criteria) but had been randomly assigned to the nontreatment group were given the antidepressant
> mirtazapine after the diagnosis of depression had been established.
> According to the researchers, 40% (14/35) of the nontreated patients and 5.7% (2/35) of the patients who
> were treated with mirtazapine developed post-stroke depression. Fifteen of these remitted after initiation of
> treatment with mirtazapine. The authors estimate that mirtazapine use will prevent 34 cases of depression for
> every 100 stroke patients treated.

Hi Ed!

Interesting study and I am not surprised. It seems that Remeron is getting a lot of positive results through clinical trials for a variey of disorders. Neurotransmitter.net has many interesting unrelated studies on Remeron. John
>

Re: Remeron for post-stroke depression

Posted by linkadge on August 13, 2005, at 22:27:51

In reply to Re: Remeron for post-stroke depression » ed_uk, posted by Nixon on August 13, 2005, at 20:38:08

I found that remeron was a fairly good drug. If only a few small changes could be made it would be a great drug.

Linkadge

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