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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by spin2003 on January 29, 2002, at 12:58:04
hi there.
I have done some research and see some lines being drawn between cocaine and effexor.
Firstly, If effexor in any way being used as method to treat cocaine dependence?
Secondly, while obviously not a good idea, what are the real risks of mixing the two? ie using cocaine while being treated with EffexorXR.
Any help and info would be much appreciated.
thanks!
Posted by kid_A on January 29, 2002, at 13:15:12
In reply to Cocaine and Effexor - quesiton, posted by spin2003 on January 29, 2002, at 12:58:04
> Secondly, while obviously not a good idea, what are the real risks of mixing the two? ie using cocaine while being treated with EffexorXR.ive done large qtys of it while on fxr, with no adverse side effects, but you have to question the whole reason why you are using to begin with... but thats a moral question, now isnt it?
Posted by TSA West on January 29, 2002, at 18:45:21
In reply to Cocaine and Effexor - quesiton, posted by spin2003 on January 29, 2002, at 12:58:04
Thank you for posting on this matter. Happy Tuesday...
"These cases of apparent adverse effects in four adolescents receiving venlafaxine manifesting marked mental status changes consistent with delirium and tachycardia after snorting cocaine highlight a drug interaction between this combination. The occurrence of four cases in one practice highlight the importance of identifying the risks of this combination.
The occurrence of a toxic, confusional state in these adolescents who were undergoing venlafaxine therapy and who used cocaine is consistent with reports of states of delirium and nonspecific confusion in cocaine users (Thomas, 1993) [27]. Hence, the achievement of delirium with relatively low doses of cocaine signals a potential drug interaction. For instance, the active compound in cocaine is metabolized by similar hepatic mitochondrial enzymes as venlafaxine (Gilman et al., 1990) [12]. An interaction with venlafaxine resulted in an elevation in serum and CNS levels of cocaine by reducing its metabolism (Gilman et al., 1990) [12}."
JAACAP 1997
Case Studies: Adverse Effects of Snorting Cocaine While Receiving Venlafaxine TreatmentWith caring,
**********TSA West-------------------- >
Posted by Elizabeth on January 30, 2002, at 18:16:24
In reply to Cocaine and Effexor - quesiton, posted by spin2003 on January 29, 2002, at 12:58:04
I don't know of any attempts to use Effexor to treat cocaine addiction. Some risks of combining the two are elevated blood pressure (which can cause, for example, stroke), cardiac arrhythmias, psychosis, and seizures (and that's just what I can think of off the top of my head).
I think the interaction is a pharmacodynamic one only.
-elizabeth
Posted by asn_sweetie on July 31, 2005, at 11:46:23
In reply to Cocaine and Effexor - quesiton, posted by spin2003 on January 29, 2002, at 12:58:04
My girlfriend and I have battled depression since we were teenagers. I think we both have bipolar because we go through stages where we run on 2 hours of sleep and are extremely overconfident and very determined to engage in high risk activites during those phases like drinking and having a desire to try drugs. We have tried XTC (lost interest because it did not do anything for us the first time. I have not have any desire to try any other drugs, but sometimes I think about it when I am in that type of mood.
We have been able to keep each other in check, we don't see the doctor during these periods because it's nice to be "high on life" and it seems to increase work productivity for us. Then the crash comes.
I am on effexor now, after a year and a half on wellbutrin. I think wellbutrin just lost its effectiveness for me.
I have been searching for information about cocaine because my girl started using it about a month and a half ago. She doesn't do very much, and reports she uses about one line every second day or so. But she says that she has not needed her medication in the last month due to this.
I have read many websites about the concerns of cocaine (as we have been taught since kinds). I just wonder because coke seems to do the same thing as effexor. I have consulted some websites and they say that despite coke being very addictive, it's not necessarily a given that everyone who uses it will get addicted.
I just want to be able to know what the difference is. The websites have been helpful in terms of side effects and addictions, but can she use coke continuously instead of her effexor?
What will happen if she ends up using both at the same time?
I work with her every day, see her every night for coffee and I have known her for twenty years, so I would notice a change in behaviour - which I have not.
I don't want her to be addicted, but is taking cocaine daily the same as taking effexor daily?
She has not been getting high and she has not used more than about a line a day (I don't know what a line is, but I have been assured it's minimal).
I asked some people at the drug addiction centre and they told me to tell her to stop. If it's the same, I don't see the difference.
Posted by Declan on July 31, 2005, at 15:51:48
In reply to Re: Cocaine and Effexor - question, posted by asn_sweetie on July 31, 2005, at 11:46:23
It can't be the same. Although one of Link's friends thought it was similar. Maybe it's worth trying after all, Effexor I mean.
Do you like Effexor?
I had a friend on a lot of Effexor and he said it did nothing for him one way or the other.
Presumably there are some people who can use cocaine in moderation, do you think?
Declan
This is the end of the thread.
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