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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by ixus on June 16, 2005, at 10:46:23
Hi all,
in that combo, Parnate 30 mg works perfect for depression, sulpiride 200 mg for anxiety and tensions. I tried risperidone before without success.
/ixus (free of floating anxiety and tensions)
Posted by ed_uk on June 16, 2005, at 10:50:24
In reply to Sulpiride + Parnate combo, posted by ixus on June 16, 2005, at 10:46:23
Hi Ixie!
Have you already tried sulpiride? Did it help?
Yours,
Ed.
Posted by xbunny on June 16, 2005, at 14:22:03
In reply to Sulpiride + Parnate combo, posted by ixus on June 16, 2005, at 10:46:23
> Hi all,
> in that combo, Parnate 30 mg works perfect for depression, sulpiride 200 mg for anxiety and tensions.I took sulpride with lofepramine for a while. The sulpride was fine, the lofepramine did nothing. For some reason I'll never understand the psychiatrist switched me from the sulpride to amisulpride. Seemed exactly the same.
Buns
Posted by ed_uk on June 16, 2005, at 14:36:16
In reply to Re: Sulpiride + Parnate combo, posted by xbunny on June 16, 2005, at 14:22:03
Hi Buns!
>For some reason I'll never understand the psychiatrist switched me from the sulpride to amisulpride. Seemed exactly the same.
Oddly enough, I have heard of people responding to one but not the other (or suffering side effects with one but not the other) - it might just be a matter of dose though.
Strangely, amisulpride is marketed as an atypical AP whereas sulpiride is considered to be a typical AP. It's ridiculous really because they're very similar.
Kind regards,
Ed.
Posted by TomG on June 17, 2005, at 20:34:43
In reply to Re: Sulpiride + Parnate combo » xbunny, posted by ed_uk on June 16, 2005, at 14:36:16
Very interesting combo. I'm glad its working for you.
Posted by SLS on June 18, 2005, at 7:34:48
In reply to Sulpiride + Parnate combo, posted by ixus on June 16, 2005, at 10:46:23
Hi Ixus.
Sulpiride sometimes works better to treat depression at dosages of 50-100mg according to a Dr. D. Bakish that I spoke to before trying it. That seemed a little low to me. I was thinking more like 100-200mg. However, 50-100mg of sulpiride equates to roughly 25-50mg of amisulpiride, a drug reported to exert antidepressant effects in this dosage range. Amisulpiride has been studied for use in dysthymia, the results of which have been positive. I think adding low-dose sulpiride or low-dose amisulpiride is worth a trial in combination with Parnate. I have not decided which of the two antipsychotics is a more powerful antidepressant. Amisulpiride has a much greater affinity for D2 receptors; greater than that of dopamine. Sulpiride is weaker than dopamine. I think it might come down to ratios of affinities of drug to pre/post-synaptic receptors. Both seem to work, though. Sulpiride monotherapy caused me to feel better for about two hours after taking my first dose of 50mg, and nothing thereafter. I still have some of it floating around, so maybe I'll repeat the trial while adding it to the drugs I'm now taking, which include Parnate and desipramine.
I experienced a brief (about 10 days), but significant improvement in depression and social anxiety when I added Zyprexa 5mg to Parnate 80mg. If anxiety is a feature of the core depressive illness, it should disappear when the depression resolves. You might not need to treat the anxiety separately.
It looks as if Ixis has found a wonderful treatment that works well for him. A lower dosage of sulpiride might not address adequately his anxiety.
- Scott
Posted by ixus on June 18, 2005, at 8:13:12
In reply to Re: Sulpiride + Parnate combo, posted by SLS on June 18, 2005, at 7:34:48
Hi Scott,
> Sulpiride sometimes works better to treat depression at dosages of 50-100mg according to a Dr. D. Bakish that I spoke to before trying it.
>This may be true, I plan to lower the dose as soon as it kicks in completely. However there are different reports about the dose and in some cases 100-300 mg is used. I read a raport where mean 180mg had been used.
I use this for primary anxiety and tensions.
>That seemed a little low to me. I was thinking more like 100-200mg. However, 50-100mg of sulpiride equates to roughly 25-50mg of amisulpiride, a drug reported to exert antidepressant effects in this dosage range. Amisulpiride has been studied for use in dysthymia, the results of which have been positive. I think adding low-dose sulpiride or low-dose amisulpiride is worth a trial in combination with Parnate. I have not decided which of the two antipsychotics is a more powerful antidepressant.
>
I would be cautious saying that either amisulpride or sulpiride possesses strong antidepressant effect.
There are many articles about amisulpride about that, however this is a new drug and is marketed very extensively.>Amisulpiride has a much greater affinity for D2 receptors; greater than that of dopamine. Sulpiride is weaker than dopamine. I think it might come down to ratios of affinities of drug to pre/post-synaptic receptors. Both seem to work, though. Sulpiride monotherapy caused me to feel better for about two hours after taking my first dose of 50mg, and nothing thereafter. I still have some of it floating around, so maybe I'll repeat the trial while adding it to the drugs I'm now taking, which include Parnate and desipramine.
>50mg is a very low dose.
A few years ago I tried amisulpride 25-100mg combined with fluoxetine. It did not help, but I can not compare it, because now I am on Parnate.> I experienced a brief (about 10 days), but significant improvement in depression and social anxiety when I added Zyprexa 5mg to Parnate 80mg. If anxiety is a feature of the core depressive illness, it should disappear when the depression resolves. You might not need to treat the anxiety separately.
>
Actually it is VERY difficult to say whethere anxiety or depression is primary. I tried to treat depression and anxiety with typical antidepressants without much success. Parnate relieves depression but anxiety remains.> It looks as if Ixis has found a wonderful treatment that works well for him. A lower dosage of sulpiride might not address adequately his anxiety.
>
We'll see. I will definitely go for a lower dose,/ixus
Posted by SLS on June 18, 2005, at 8:57:18
In reply to Re: Sulpiride + Parnate combo » SLS, posted by ixus on June 18, 2005, at 8:13:12
Hi again, Ixus.
> > Sulpiride sometimes works better to treat depression at dosages of 50-100mg according to a Dr. D. Bakish that I spoke to before trying it.
> This may be true, I plan to lower the dose as soon as it kicks in completely. However there are different reports about the dose and in some cases 100-300 mg is used. I read a raport where mean 180mg had been used.
> I use this for primary anxiety and tensions.> > I have not decided which of the two antipsychotics is a more powerful antidepressant.
> I would be cautious saying that either amisulpride or sulpiride possesses strong antidepressant effect.
I agree. Thanks for pointing that out.
> There are many articles about amisulpride about that, however this is a new drug and is marketed very extensively.
Yes. It is unfortunate that the volume of studies involving a particular drug should be tied in to its potential marketability as encouraged by the manufacturer. Some old drugs work well, but have not been studied using the new technology because people have lost interest in them. Occasionally, the older drugs are used in pure science (as opposed to investigative clinical medicine) because their properties have been well established and can be counted on for quantification in experiments.
> >Amisulpiride has a much greater affinity for D2 receptors; greater than that of dopamine. Sulpiride is weaker than dopamine. I think it might come down to ratios of affinities of drug to pre/post-synaptic receptors. Both seem to work, though. Sulpiride monotherapy caused me to feel better for about two hours after taking my first dose of 50mg, and nothing thereafter. I still have some of it floating around, so maybe I'll repeat the trial while adding it to the drugs I'm now taking, which include Parnate and desipramine.
> 50mg is a very low dose.
Maybe I should target 100mg from the outset. I probably would.
> A few years ago I tried amisulpride 25-100mg combined with fluoxetine. It did not help, but I can not compare it, because now I am on Parnate.
> > I experienced a brief (about 10 days), but significant improvement in depression and social anxiety when I added Zyprexa 5mg to Parnate 80mg. If anxiety is a feature of the core depressive illness, it should disappear when the depression resolves. You might not need to treat the anxiety separately.> Actually it is VERY difficult to say whethere anxiety or depression is primary. I tried to treat depression and anxiety with typical antidepressants without much success. Parnate relieves depression but anxiety remains.
> > It looks as if Ixis has found a wonderful treatment that works well for him. A lower dosage of sulpiride might not address adequately his anxiety.
> We'll see. I will definitely go for a lower dose,One way or the other, I am very happy that found an effective treatment. There haven't been too many success stories posted here over the last few days.
- Scott
Posted by michael on December 5, 2005, at 18:47:48
In reply to Re: Sulpiride + Parnate combo, posted by xbunny on June 16, 2005, at 14:22:03
> > Hi all,
> > in that combo, Parnate 30 mg works perfect for depression, sulpiride 200 mg for anxiety and tensions.
>
> I took sulpride with lofepramine for a while. The sulpride was fine, the lofepramine did nothing. For some reason I'll never understand the psychiatrist switched me from the sulpride to amisulpride. Seemed exactly the same.
>
> Buns
>Hi-
Just wondering, were you taking the sulpiride/amisulpride for depression/dysthymia?
Also wondering what doses you were taking? (for each of the meds) Thanks for any feedback. michael
Posted by xbunny on December 9, 2005, at 3:33:50
In reply to Re: Sulpiride + Parnate combo » xbunny, posted by michael on December 5, 2005, at 18:47:48
Hi I just noticed this post but I thought I should reply even though its a bit old now.
> Just wondering, were you taking the sulpiride/amisulpride for depression/dysthymia?
My DX at the time was psychotic depression it has since changed to schizophrenia.
>
> Also wondering what doses you were taking? (for each of the meds) Thanks for any feedback.I was a long time ago, I think I was taking 400mg for both.
Buns
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