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Dr. Bob is Robert Hsiung, MD,
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Posted by ed_uk on June 17, 2005, at 20:07:59
Zonisamide, an antiepileptic, is already available in the US. It's been popular in Japan for many years. I know a few babblers have tried it for bipolar disorder - it's always good to have options. Well, now we've got the Zonegran option in the UK too..........
See the picture of Zonegran....
http://www.pharmj.com/Editorial/20050618/products/p757products.html
Zonegran
Composition: Zonisamide.
Presentation: Hard capsules.
Class: Anti-epileptic agent.
Indications: Adjunctive therapy in the treatment of adult patients with partial seizures, with or without secondary generalisation.
Dosage: The recommended initial daily dose is 50mg in two divided doses. After one week the dose may be increased to 100mg daily and thereafter the dose may be increased at one weekly intervals, in increments of up to 100mg. Zonegran can be administered once or twice daily after the titration phase. Caution should be exercised at initiation of treatment in elderly patients. Zonegran’s safety and effectiveness in children and adolescents under 18 years have not been established.
Precautions: Caution must be exercised in treating patients with renal impairment. Use in patients with severe hepatic impairment is not recommended. Caution must be exercised in treating patients with mild to moderate hepatic impairment.
Side effects: Very common (>1/10) anorexia, agitation, irritability, confusional state, depression, ataxia, dizziness, memory impairment, somnolence, diplopia. Common (>1/100) hypersensitivity, disturbance in attention, speech disorder, abnormal gastrointestinal pain, diarrhoea, nausea, rash, pyrexia, weight decrease.
Legal category: P*M.
Net price: 25mg 14 £8.82, 50mg 56 £47.04, 100mg 56 £62.72.
Contact details: Eisai, 3 Shortlands, London W6 8EE. Telephone 020 8600 1400.~Ed
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