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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by ed_uk on May 20, 2005, at 18:30:08
An interesting study...... it could be relevent to the (generally) poor efficacy of moclobemide.
Hokkaido Igaku Zasshi. 2001 May;76(3):133-42.
A behavioral and neurochemical study on the mechanism of the anxiolytic effect of monoamine oxidase inhibitors
[Article in Japanese]
Maki Y.
Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
The author examined the acute anxiolytic effects of monoamine oxidase inhibitors on freezing behavior, a putative index of anxiety, induced by conditioned fear stress. The selective serotonin1A receptor agonist inhibited freezing dose dependently. The irreversible, non-selective monoamine oxidase inhibitors tranylcypromine (3 and 15 mg/kg) and phenelzine (30 and 80 mg/kg) reduced freezing significantly. Clorgyline (10 mg/kg, irreversible selective monoamine oxidase A inhibitor), Ro 41-1049 (30 mg/kg, reversible selective monoamine oxidase A inhibitor), selegiline (3 mg/kg, irreversible selective monoamine oxidase B inhibitor) and lazabemide (10 mg/kg, reversible selective monoamine oxidase B inhibitor) had no effect on freezing behavior. However, combined administration of clorgyline (10 mg/kg) and selegiline (3 mg/kg) reduced freezing significantly, as well as combined administration of clorgyline (10 mg/kg) and lazabemide (10 mg/kg), Ro 41-1049 (30 mg/kg) and selegiline (3 mg/kg), or Ro 41-1049 (30 mg/kg) and lazabemide (10 mg/kg). These effects of monoamine oxidase inhibitors on freezing were not due to non-specific motor effects. These results suggest that acute inhibition of both monoamine oxidase A and B reduces anxiety or fear, while inhibition of monoamine oxidase A or B alone fails to reduce anxiety or fear. In vivo microdialysis studies showed that the irreversible monoamine oxidase A inhibitor clorgyline and the irreversible monoamine oxidase B inhibitor selegiline induced a mild increase and no increase in extracellular serotonin, respectively. Interestingly, the combined treatment with clorgyline and selegiline resulted in much larger increases in extracellular serotonin in the medial prefrontal cortex than did either monoamine oxidase inhibitor alone. Our previous studies have indicated that facilitation of 5-HT neurotransmission decreases conditioned freezing, i.e., anxiety or fear. The results of these in vivo microdialysis studies may account for the results of this study that the simultaneous blockade of both monoamine oxidase A and B reduced conditioned freezing, whereas blockade of either monoamine oxidase alone failed.
PS. I have a textbook that claims moclobemide should be viewed as replacement for Nardil, what a load of rubbish!
Posted by sdb on May 20, 2005, at 19:11:08
In reply to Moclobemide (Manerix, Aurorix) is a bit rubbish..., posted by ed_uk on May 20, 2005, at 18:30:08
Hi ed nice to hear from you!
I did not read the abstract but - poorly moclobemide is the only MAO available in my country and it did <nothing>. I cant believe that this one is prescribed for social phobia!
It even caused some minor depression.
But as always, its my personal experience
sdb
Posted by Alvin on May 20, 2005, at 20:53:20
In reply to Moclobemide (Manerix, Aurorix) is a bit rubbish..., posted by ed_uk on May 20, 2005, at 18:30:08
Ed, with your background, perhaps you can give me more insight into the workings of aripiprazole (Abilify) and its unique mechanism as both agonist/antagonist on dopamine/serotonin receptors. Altho short trials of SSRI's were helpful, I eventually became apathetic and developed serotonin syndrome on prozac. I also have to be careful of mood destabilization. Is The partial agonist activity of aripiprazole helpful in preventing serotonin syndrome? Thanks for any help.
Posted by ixus on May 21, 2005, at 2:26:00
In reply to Moclobemide (Manerix, Aurorix) is a bit rubbish..., posted by ed_uk on May 20, 2005, at 18:30:08
Hi Ed,
This is all about money. It seems US FDA is less corrupted (or better informed) than EU institutions. I have not meet any pdoc claiming that moclobemide has any therapeutic effect.
/ixus> PS. I have a textbook that claims moclobemide should be viewed as replacement for Nardil, what a load of rubbish!
>
Posted by ixus on May 21, 2005, at 2:32:05
In reply to Re: Moclobemide (Manerix, Aurorix) is a bit rubbish..., posted by sdb on May 20, 2005, at 19:11:08
Hi sdb,
> I did not read the abstract but - poorly moclobemide is the only MAO available in my country and it did <nothing>. I cant believe that this one is prescribed for social phobia!
Where do you live?
/ixus
Posted by alienatari on May 21, 2005, at 5:51:07
In reply to Moclobemide (Manerix, Aurorix) is a bit rubbish..., posted by ed_uk on May 20, 2005, at 18:30:08
Ahh I remember when I was on Moclobemide, it was utter crap I totally agree with you!!!
That study is really interesting.
My friend has just been put on it and asked me what do I think, I didnt know what to say =/
Take care
> An interesting study...... it could be relevent to the (generally) poor efficacy of moclobemide.
>
> Hokkaido Igaku Zasshi. 2001 May;76(3):133-42.
>
> A behavioral and neurochemical study on the mechanism of the anxiolytic effect of monoamine oxidase inhibitors
>
> [Article in Japanese]
>
> Maki Y.
>
> Department of Psychiatry, Neural Function, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
>
> The author examined the acute anxiolytic effects of monoamine oxidase inhibitors on freezing behavior, a putative index of anxiety, induced by conditioned fear stress. The selective serotonin1A receptor agonist inhibited freezing dose dependently. The irreversible, non-selective monoamine oxidase inhibitors tranylcypromine (3 and 15 mg/kg) and phenelzine (30 and 80 mg/kg) reduced freezing significantly. Clorgyline (10 mg/kg, irreversible selective monoamine oxidase A inhibitor), Ro 41-1049 (30 mg/kg, reversible selective monoamine oxidase A inhibitor), selegiline (3 mg/kg, irreversible selective monoamine oxidase B inhibitor) and lazabemide (10 mg/kg, reversible selective monoamine oxidase B inhibitor) had no effect on freezing behavior. However, combined administration of clorgyline (10 mg/kg) and selegiline (3 mg/kg) reduced freezing significantly, as well as combined administration of clorgyline (10 mg/kg) and lazabemide (10 mg/kg), Ro 41-1049 (30 mg/kg) and selegiline (3 mg/kg), or Ro 41-1049 (30 mg/kg) and lazabemide (10 mg/kg). These effects of monoamine oxidase inhibitors on freezing were not due to non-specific motor effects. These results suggest that acute inhibition of both monoamine oxidase A and B reduces anxiety or fear, while inhibition of monoamine oxidase A or B alone fails to reduce anxiety or fear. In vivo microdialysis studies showed that the irreversible monoamine oxidase A inhibitor clorgyline and the irreversible monoamine oxidase B inhibitor selegiline induced a mild increase and no increase in extracellular serotonin, respectively. Interestingly, the combined treatment with clorgyline and selegiline resulted in much larger increases in extracellular serotonin in the medial prefrontal cortex than did either monoamine oxidase inhibitor alone. Our previous studies have indicated that facilitation of 5-HT neurotransmission decreases conditioned freezing, i.e., anxiety or fear. The results of these in vivo microdialysis studies may account for the results of this study that the simultaneous blockade of both monoamine oxidase A and B reduced conditioned freezing, whereas blockade of either monoamine oxidase alone failed.
>
> PS. I have a textbook that claims moclobemide should be viewed as replacement for Nardil, what a load of rubbish!
>
This is the end of the thread.
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