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Dr. Bob is Robert Hsiung, MD,
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Posted by Peter S. on April 12, 2005, at 0:07:20
After the promising study of Omega 3s and uridine for depression in rats, it looks like RepliGen is moving ahead.
Check this out (www.repligen.com)Repligen and The Stanley Medical Research Institute Enter Development Agreement for Uridine for Bipolar Disorder
WALTHAM, MA - March 14, 2005 - Repligen Corporation (NASDAQ: RGEN) today announced that the Company has entered into a development agreement with the Stanley Medical Research Institute under which Repligen will receive funding for a Phase 1 clinical trial to assess the oral bioavailability of Repligen's proprietary formulation of uridine. This Phase 1 study is expected to enroll patients next quarter and follows Repligen's preliminary findings in animal models and patients that uridine may be useful in treating the depressive symptoms of bipolar disorder. The Stanley Medical Research Institute is the largest nonprofit provider of funding for research on schizophrenia and bipolar disorder in the United States."We are very pleased to receive this grant from The Stanley Medical Research Institute, a world leader in the support and development of new drugs for bipolar disorder and schizophrenia," stated Walter C. Herlihy, President and Chief Executive Officer of Repligen. "If this study is successful, we look forward to extending this partnership through Phase 2 studies in patients with bipolar disorder."
"This clinical study will provide us valuable information to help design a Phase 2 study to assess the potential of uridine in bipolar disorder," stated Dr. Michael Knable, Executive Director of The Stanley Medical Research Institute.
In 2004, Repligen completed a 6-week Phase 1 clinical trial of a prodrug of a uridine (RG2133) in patients with bipolar disorder or major depression. The results demonstrated that administration of RG2133 in this patient population appeared to be safe, did not induce mania, a potential side effect of existing therapies, and provided early evidence of a clinical effect of the drug. The trial evaluated 19 patients and was carried out by investigators at McLean Hospital, the largest psychiatric clinical care, teaching and research affiliate of Harvard Medical School.
Uridine is a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the power plant of the human cell known as the mitochondria. The rationale for uridine therapy in neuropsychiatric disorders is supported by pre-clinical and clinical research. Researchers at McLean Hospital previously demonstrated that uridine is active in a well-validated animal model of depression. Recent reports indicate that certain genes that encode for mitochondrial proteins are significantly down regulated in the brains of bipolar patients. This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy metabolism of the brain.
Posted by Ritch on April 12, 2005, at 10:10:31
In reply to Uridine- Phase I trial, posted by Peter S. on April 12, 2005, at 0:07:20
>...Uridine is a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism. Uridine is synthesized by the power plant of the human cell known as the mitochondria. The rationale for uridine therapy in neuropsychiatric disorders is supported by pre-clinical and clinical research. Researchers at McLean Hospital previously demonstrated that uridine is active in a well-validated animal model of depression. Recent reports indicate that certain genes that encode for mitochondrial proteins are significantly down regulated in the brains of bipolar patients. This new insight suggests that the symptoms of bipolar disorder may be linked to dysregulation of energy metabolism of the brain.
Hey, thanks for posting that! "Dysregulation of energy metabolism of the brain"... wow, I think they may be closing in on the real trouble. Fundamentally, I would agree that it is an energy management problem, and all the symptoms stem from that....
Posted by lunesta on April 12, 2005, at 19:28:04
In reply to Uridine- Phase I trial, posted by Peter S. on April 12, 2005, at 0:07:20
Uridine is one of the main parts of the chemical formula for the drug Ampligen, the only immune system drug being approved and proved to treat and cure chronic fatigue syndrome and AIDS.
This is the end of the thread.
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