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Dr. Bob is Robert Hsiung, MD,
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Posted by Raymond L Belger on January 26, 2005, at 10:11:16
I have been taking XANAX for over three years and recently I noticed where they posted a warning not to us grapefruit juice while taking this medication. What is the danger as additionally, I mix Grapefruit with alcohol. Please let me know at your convenience as I have just recently seen this warning on my bottle.
Posted by tensor on January 26, 2005, at 10:56:09
In reply to Grapefruit Juice While Taking XANAX, posted by Raymond L Belger on January 26, 2005, at 10:11:16
Posted by Kon on January 26, 2005, at 12:46:59
In reply to Grapefruit Juice While Taking XANAX, posted by Raymond L Belger on January 26, 2005, at 10:11:16
I think it was suspected that there will be an interaction because some other benzos like valium have been shown to have an enhanced effect with grapefruit. But this is unlikely to occur with xanax (see abstract below).
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Psychopharmacology (Berl). 2000 Jun;150(2):185-90.Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam.
Yasui N, Kondo T, Furukori H, Kaneko S, Ohkubo T, Uno T, Osanai T, Sugawara K, Otani K.Department of Neuropsychiatry, Hirosaki University School of Medicine, Japan.
The effects of repeated ingestion of grapefruit juice, an inhibitor of cytochrome P450 3A4 (CYP3A4), on the pharmacokinetics and pharmacodynamics of both single and multiple oral doses of alprazolam, a substrate of CYP3A4, were examined. In study 1, eight healthy volunteers ingesting 600 ml/day water or grapefruit juice for 10 days took a single oral 0.8-mg dose of alprazolam on the eighth day. Plasma drug concentrations were monitored up to 48 h after alprazolam dosing together with evaluation of psychomotor function. Grapefruit juice altered neither the plasma concentrations of alprazolam at any time points, any pharmacokinetic parameters, nor the majority of psychomotor function parameters in subjects. In study 2, 11 patients with anxiety disorders receiving alprazolam (0.8-2.4 mg/day) ingested grapefruit juice (600 ml/day) for 7 days. Blood samples were collected before and during grapefruit juice ingestion and 1 week after its discontinuation together with an assessment of clinical status. Grapefruit juice altered neither the steady-state plasma concentration of alprazolam nor the clinical status in patients. The present study shows that grapefruit juice is unlikely to affect pharmacokinetics or pharmacodynamics of alprazolam due to its high bioavailability.
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