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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Kon on January 25, 2005, at 12:52:03
Just curious, has anybody experimented with combining the two to increase the effectiveness of any benzo. Grapefruit seems to increase the bioavailability of a number of benzos (esp Valium) and other drugs by inhibiting some of the enzymes (i.e. CYP3A4) that metabolize these drugs. It seems to have less effect on clonazepam/xanax, however. I've come across papers suggesting a potential therapeutic benefit in using grapefruit to increase drug bioavailibility. Any experiences?
Posted by paulbwell on January 26, 2005, at 3:13:30
In reply to Benzos and Grapefruit juice, posted by Kon on January 25, 2005, at 12:52:03
> Just curious, has anybody experimented with combining the two to increase the effectiveness of any benzo. Grapefruit seems to increase the bioavailability of a number of benzos (esp Valium) and other drugs by inhibiting some of the enzymes (i.e. CYP3A4) that metabolize these drugs. It seems to have less effect on clonazepam/xanax, however. I've come across papers suggesting a potential therapeutic benefit in using grapefruit to increase drug bioavailibility. Any experiences?
>
>Yep, I have, it increases cmax by 1.5%
althought delays this til 2 hours2mgs (white) becomes 3mgs
5mgs (yellow) becomes 7.5mgs
10mgs (blue) becomes 15mgsYou get the picture
Posted by tensor on January 26, 2005, at 6:57:25
In reply to Valium+Grapefruit juice=1.5% increase, posted by paulbwell on January 26, 2005, at 3:13:30
> Yep, I have, it increases cmax by 1.5%
> althought delays this til 2 hours
>
> 2mgs (white) becomes 3mgs
> 5mgs (yellow) becomes 7.5mgs
> 10mgs (blue) becomes 15mgsWouldn't that be 150%? Maybe you mean 1,5x? :-)
/Mattias
Posted by paulbwell on January 26, 2005, at 11:14:25
In reply to Re: Valium+Grapefruit juice=1.5% increase » paulbwell, posted by tensor on January 26, 2005, at 6:57:25
>
> > Yep, I have, it increases cmax by 1.5%
> > althought delays this til 2 hours
> >
> > 2mgs (white) becomes 3mgs
> > 5mgs (yellow) becomes 7.5mgs
> > 10mgs (blue) becomes 15mgs
>
> Wouldn't that be 150%? Maybe you mean 1,5x? :-)
>
> /Mattias
>DOH! yes 1.5x or 150%
Posted by Minnie-Haha on January 26, 2005, at 15:30:52
In reply to Benzos and Grapefruit juice, posted by Kon on January 25, 2005, at 12:52:03
I wouldn't make grapefruit juice a regular part of your diet if you take cholesterol lowering drugs (statins). Something about that combo can potentially mess up your muscles.
Posted by gromit on January 29, 2005, at 7:12:22
In reply to Benzos and Grapefruit juice, posted by Kon on January 25, 2005, at 12:52:03
It messes with Buspar too, Ranitidine is another one that causes problems with TCA's and benzo's and probably others. It's too bad because Ranitidine is one of the only things that helps my heartburn.
Rick
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