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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by ed_uk on December 20, 2004, at 18:27:12
Hi,
Sibutramine (Meridia / Reductil) is a serotonin and norepinephrine reuptake inhibitor, it also inhibits dopamine reuptake to a lesser extent. It is used as a treatment for obesity. Suprisingly, the development of sibutramine as an antidepressant was discontinued due to apparant lack of efficacy in clinical trials.
Has anyone ever found sibutramine to be a useful treatment for depression?
Ed.
Posted by SLS on December 20, 2004, at 20:16:06
In reply to Sibutramine (Meridia / Reductil) and depression, posted by ed_uk on December 20, 2004, at 18:27:12
> Hi,
>
> Sibutramine (Meridia / Reductil) is a serotonin and norepinephrine reuptake inhibitor, it also inhibits dopamine reuptake to a lesser extent. It is used as a treatment for obesity. Suprisingly, the development of sibutramine as an antidepressant was discontinued due to apparant lack of efficacy in clinical trials.
>
> Has anyone ever found sibutramine to be a useful treatment for depression?
>
> Ed.
I didn't know there was a lack of efficacy. The drug company developing the (R-) enantiomer of sibutramine as an antidepressant announced that they temporarily dropped the project for lack of funds. I don't know. I know of one doctor who swears by sibutamine. I would be quick to try it if there weren't so many restrictions on its use by my prescription plan. They require one to give details as to their height and weight to determine eligibility for coverage. I am not overweight enough to meet the requirements. I have no idea how Meridia costs.
- Scott
Posted by darkhorse on December 21, 2004, at 5:26:13
In reply to Sibutramine (Meridia / Reductil) and depression, posted by ed_uk on December 20, 2004, at 18:27:12
Hi Ed,
I took Sibutramine and oh! boy, what a medication!!.
First day I was stimulated and felt very good and thought that is the one : Antidepressant+No weight gain!! but.....
next few days I became more and more agitated,irritated and I would scream and shout for any little thing.
I was a walking bomb!!(not unlike Milnacipran).....
I added Fluoxetine to smooth my temper and a benzo but nothing!...
I think I stayed on it for maybe 2-3 monthes..
I do not know how my family survived me!!I think I lost maybe 1-2 kilos!!....but what is worse I developed an abnormal arrithmyia which made me discontinue immediatley.
Once I stopped, the nightmare stopped,but arrythmiya(spelling!!) continued and I consulted a cardio and he diagnosed me with ventriqular arrythmia and I took veerapamil and tenormin for few monthes then stopped,and gradually and thank God, this disorder stopped.
For me,this medication proved a total faliure for weight loss and depression,and dangerous as it triggered agression and life- threatining as it certainly did harm to my otherwise perfectly healthy heart.(You know I tried lots of TCAs and NEVER had the slightest heart problem).
IMOHO this is a very expensive drug with little proven benefits and lots of risks,and,frankly, I do not hear about it...
Just my experience...Best regards,
Adam.
This is the end of the thread.
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