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Dr. Bob is Robert Hsiung, MD,
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Posted by joebob on May 8, 2004, at 9:36:50
into histamine and trazadone?
if i find trazadone so effective, does it imply that i am high histamine?
if so what other stratagies can i use to lower histamine?keep up the good work and keep posting
thnx
joebob
Posted by chemist on May 8, 2004, at 23:22:52
In reply to chemist....can you give me a little more insight, posted by joebob on May 8, 2004, at 9:36:50
> into histamine and trazadone?
> if i find trazadone so effective, does it imply that i am high histamine?
> if so what other stratagies can i use to lower histamine?
>
> keep up the good work and keep posting
>
> thnx
>hi joebob, trazodone likes to bind to a histaminergic receptor (H_{1}), among others, and the sedating effect is largely attributable to this modality...but if it is working for you in the capacity as a sedative, then it is doing its job (and it does not stimulate histamine production/depletion, it has a very similar binding affinity for the receptor in question as histamine itself, so-called competitive binding)...if you are taking it as an anti-depressant and the sedation is affecting you but the depression has been tempered, perhaps an alternative med that targets the alpha_{1}-NA and 5-HT_{2} receptors but has lower affinity for H_{1} is called for....i defer to the other posters for suggestions, as i have little knowledge of a suitable substitute.....apologies for a dead-end, and all the best, chemist
> joebob
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