Psycho-Babble Medication Thread 332475

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seroquel with an ssri

Posted by dondon on April 4, 2004, at 11:03:17

Wouldn't seroquel antagonize the effects of ssris?
It is a 5-ht1a antagonist and the ssris work by stimulating this receptor so wouldn't it make the ssri not work as well?

Re: seroquel with an ssri » dondon

Posted by Sad Panda on April 5, 2004, at 13:10:44

In reply to seroquel with an ssri, posted by dondon on April 4, 2004, at 11:03:17

> Wouldn't seroquel antagonize the effects of ssris?
> It is a 5-ht1a antagonist and the ssris work by stimulating this receptor so wouldn't it make the ssri not work as well?
>
>

Hi dondon,

I think you mean 5-HT2A antagonist. In theory it should mean that there is more serotonin for the other 5-HT recptors, but in reality I don't think it makes much difference. Extra serotonin available to the 5-HT1 receptors it thought to be the mechanism that gives SSRI's their postive effect.

Cheers,
Panda.

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