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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by francesco on March 8, 2004, at 8:14:40
I'm asking because my psychiatrist put me on Parnate after just two days I quit Desipraminine. Does anybody have precise info of what reaction can occurr ? Thanks
Posted by King Vultan on March 8, 2004, at 8:27:09
In reply to what happenes if wash out is not respected ?, posted by francesco on March 8, 2004, at 8:14:40
> I'm asking because my psychiatrist put me on Parnate after just two days I quit Desipraminine. Does anybody have precise info of what reaction can occurr ? Thanks
Theoretically, you can get hyperpyrexia from mixing an MAOI and tricyclic, but these two classes of drugs are sometimes cautiously combined. This whole MAOI/tricyclic thing is a gray area, but regardless, your psychiatrist's actions would strike some people as imprudent. My doctor made me wait two weeks after discontinuing desipramine before starting Nardil. However, perhaps your doctor has more experience and insight in this area than my doctor and I do.Todd
Posted by Sad Panda on March 8, 2004, at 9:39:18
In reply to what happenes if wash out is not respected ?, posted by francesco on March 8, 2004, at 8:14:40
> I'm asking because my psychiatrist put me on Parnate after just two days I quit Desipraminine. Does anybody have precise info of what reaction can occurr ? Thanks
>
>Nothing bad will happen as you can mix some MAOI's & TCA's.
A TCA you can't take with an MAOI is Clomipramine(Anafranil) as it a potent serotonin reuptake inhibitor. Another to avoid would be Imipramine(Tofranil) as it is mild serotonin reuptake inhibitor. These may give serotonin syndrome.
Cheers,
Panda.
Posted by King Vultan on March 8, 2004, at 12:07:53
In reply to Re: what happenes if wash out is not respected ?, posted by Sad Panda on March 8, 2004, at 9:39:18
> > I'm asking because my psychiatrist put me on Parnate after just two days I quit Desipraminine. Does anybody have precise info of what reaction can occurr ? Thanks
> >
> >
>
> Nothing bad will happen as you can mix some MAOI's & TCA's.
>
> A TCA you can't take with an MAOI is Clomipramine(Anafranil) as it a potent serotonin reuptake inhibitor. Another to avoid would be Imipramine(Tofranil) as it is mild serotonin reuptake inhibitor. These may give serotonin syndrome.
>
> Cheers,
> Panda.
>
>I would add amitriptyline to this list even though I have seen this combination not contraindicated in another reference. Amitriptyline's main effect is its H1 histamine blockade, but it is still relatively serotonergic (selectivity ratio 1.6 to 1 in favor of NE reuptake blockade over serotonin reuptake blockade).
Todd
This is the end of the thread.
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