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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by bipolarspectrum on March 6, 2004, at 0:12:24
Hi,
I tried reboxetine awhile back and found that it significantly helped with my depression and anxiety... However, I could not tolerate the side-effects.. I'm wondering if anyone has tried Strattera and reboxetine and whether Strattera was more tolerable than reboxetine?
Thanx for the read
Posted by Sad Panda on March 6, 2004, at 1:49:27
In reply to Anyone tried Reboxetine and STRATTERA?????????????, posted by bipolarspectrum on March 6, 2004, at 0:12:24
> Hi,
> I tried reboxetine awhile back and found that it significantly helped with my depression and anxiety... However, I could not tolerate the side-effects.. I'm wondering if anyone has tried Strattera and reboxetine and whether Strattera was more tolerable than reboxetine?
> Thanx for the readI can't help you, but I would like to know what side effects you had with Reboxetine.
Cheers,
Panda.
Posted by bipolarspectrum on March 6, 2004, at 2:26:45
In reply to Re: Anyone tried Reboxetine and STRATTERA????????????? ?bipolarspectrum, posted by Sad Panda on March 6, 2004, at 1:49:27
Hey Panda,
I had the classic anti-cholinergic side-effects, dry mouth and urinary problems... plus insomnia
but the drug was very calming and depression-alleviating...
> I can't help you, but I would like to know what side effects you had with Reboxetine.
>
> Cheers,
> Panda.
>
>
>
Posted by Sad Panda on March 6, 2004, at 2:56:26
In reply to Re: Anyone tried Reboxetine and STRATTERA?????????????, posted by bipolarspectrum on March 6, 2004, at 2:26:45
>
> Hey Panda,
> I had the classic anti-cholinergic side-effects, dry mouth and urinary problems... plus insomnia
> but the drug was very calming and depression-alleviating...
>
>Thanks for the speedy reply. :) Did you try it for long or were the side effects to harsh to continue using? Did it give you any drive or motivation? I am on a brew of Effexor & Remeron, I feel 'half-cured' but am looking for more.
Cheers,
Panda.
Posted by King Vultan on March 6, 2004, at 12:09:54
In reply to Re: Anyone tried Reboxetine and STRATTERA?????????????, posted by bipolarspectrum on March 6, 2004, at 2:26:45
>
> Hey Panda,
> I had the classic anti-cholinergic side-effects, dry mouth and urinary problems... plus insomnia
> but the drug was very calming and depression-alleviating...
>
> > I can't help you, but I would like to know what side effects you had with Reboxetine.
> >
> > Cheers,
> > Panda.
> >
Reboxetine is not actually anticholinergic to any significant degree AFAIK; the adverse effects you experienced are actually due to its strong blockade of norepinephrine reuptake. It seems as though some of these drugs that are not particularly anticholinergic but that are strong NE reuptake inhibitors, such as Strattera, reboxetine, and desipramine, often get the anticholinergic label when most of their side effects are actually directly attributable to their blockade of NE reuptake.Drugs that truly are anticholinergic, such as Vivactil (protriptyline) and imipramine, will manifest the same effects (other than the insomnia you mentioned, which is a pure NE effect), but their degree of severity is much worse. I've tried nortriptyline, desipramine, Vivactil, and Strattera, all of which are strong NE reuptake inhibitors, and while all caused me dry mouth and constipation, and most of them urinary hesitation/retention, these side effects on Vivactil were magnified and much more severe in their intensity. Vivactil does have a tremendous natural affinity for acetylcholine muscarinic receptors, being the 2nd most potent in vitro among the tricyclics (behind amitriptyline).
So in answer to your question, Strattera is likely to give you similar effects as to what you experienced on reboxetine, as will desipramine and nortriptyline. However, you may find that nortriptyline and desipramine are better for insomnia, particularly, nortriptyline. I believe you would also find nortriptyline to cause much fewer urinary difficulties, if my own experience is any kind of indication.
Todd
Posted by zeugma on March 6, 2004, at 12:55:06
In reply to Re: Anyone tried Reboxetine and STRATTERA?????????????, posted by King Vultan on March 6, 2004, at 12:09:54
Nortriptyline is somewhat sedating, especially when I combine it with buspirone. It was the combination of nortriptyline and buspirone that began to make a dent in my insomnia.
Nortriptyline by itself does sedate, but it's a little tricky, because it takes about 8 hours to reach peak plasma levels in the blood. The lower the dose, the earlier i had to take it to get a sedative effect. At 40-50 mg/day, I took it at 2 pm to be asleep by 12. At 60 mg/day, I could push it back to 4 pm. At 75 mg, I can take it at around 7:30 and be asleep by 11. All of this, however, occurs most reliably when potentiated by buspirone (otherwise I'm often up all night).
Buspirone gets the 'placebo' rap so often, and its ridiculously short half life means I have to take it bid, so i often 'forget' to take it, and wind up with insomnia, or really bad sleep quality.
Posted by T-rotten on March 6, 2004, at 18:49:42
In reply to Anyone tried Reboxetine and STRATTERA?????????????, posted by bipolarspectrum on March 6, 2004, at 0:12:24
> Hi,
> I tried reboxetine awhile back and found that it significantly helped with my depression and anxiety... However, I could not tolerate the side-effects.. I'm wondering if anyone has tried Strattera and reboxetine and whether Strattera was more tolerable than reboxetine?
> Thanx for the readI am wanting to go with reboxetine too. But as I have no access to Strattera what about bupropion or amineptine(avaliable here)?
Tanks T
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