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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Paul27 on August 8, 2003, at 9:36:48
Hi all.
I reside in the uk and suffer from severe anxiety. I am a male, 27 years old.
Either during or after any social interactions (especially performance related) i suffer from all the classic signs, faint heart, heavy breathing, burning face, heart palpitations and a sort of pit of nerves in the center of my body. Sometimes this lasts for hours after the said event.This is now severely affecting my life especially concerning developing relationships. It's just not possible, when everytime you meet and talk to people, your brain goes into overload and the mental effects of the anxiety then affect your performance not to mention the physical symptoms. Add to all this my feeling of intense dread and fear that i'm going through at the time which makes me drive to avoid or end the situation.
I don't think these issues are generally as well understood here in the uk as they are in the usa. I have desperately tried to explain these feelings to my GP and numerous councillors but they clearly don't understand, and basically say that everyone suffers from this and i'm just being stupid and weak.
I have tried various classes of drugs, ssri's, tricyclics to no avail.
I asked my GP if i could try some of the more potent drugs such as nardil, but he said its a no-no in this country with Maoi's (which seems silly to me because one possible helping factor has had the door shut on it before i even tried it)
Does anybody know any way around this in the uk?As for other avenues, the resources just dont seem to be available here in this country, and it seems that unless you are going around bashing people, the mental health service doesn't want to know.
I now feel i am in serious trouble and am running out of legal methods to sort this problem out.
Please help.paul
Posted by DSCH on August 9, 2003, at 2:29:35
In reply to What road do i take? Nardil?, posted by Paul27 on August 8, 2003, at 9:36:48
Paul,
Check out this chart. You can search for hits on social phobia using the "Find on this page" function if you're using Internet Explorer.
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
This one in particular you might want to look into: Moclobemide (Aurorix, Manerix, Moclamine). It is a RIMA (reversable inhibitor of monoamine oxidase) meaning that there isn't the "cheese effect" with tyrosine causing hypertensive crisis that exists with MAOIs like Nardil.
Posted by DSCH on August 9, 2003, at 2:45:26
In reply to What road do i take? Nardil?, posted by Paul27 on August 8, 2003, at 9:36:48
Another RIMA, which I've not heard of before, is being sold somewhere (not in the USA!) under the name Consonar.
Posted by SLS on August 9, 2003, at 8:15:42
In reply to There's also brofaromine » Paul27, posted by DSCH on August 9, 2003, at 2:45:26
> Another RIMA, which I've not heard of before, is being sold somewhere (not in the USA!) under the name Consonar.
It is my understanding that brofaromine is no longer being marketed anywhere in the world. If it were, I would give it a try myself. It combined 5-HT reuptake inhibition with its RIMA properties.
- Scott
Posted by Ame Sans Vie on August 9, 2003, at 10:16:02
In reply to Re: There's also brofaromine, posted by SLS on August 9, 2003, at 8:15:42
Gee. Sounds like brofaromine should be contraindicated in people taking brofaromine, lol! I mean, with the combined MAO-A inhibition and 5-HT reuptake inhibition, wouldn't there be the same risk of serotonin syndrome as taking, say, Nardil with Zoloft? Perhaps that's why it's no longer sold?
Posted by DSCH on August 9, 2003, at 11:37:58
In reply to Re: There's also brofaromine » SLS, posted by Ame Sans Vie on August 9, 2003, at 10:16:02
Doing a google search on "Consonar" doesn't return any ads, online pharmacy hits, or data sheets. Not a hopeful sign for its current availability.
However there is another RIMA on that chart that got missed because it was missing social anxiety or social phobia in the usage column. And that's toloxatone, which is probably available in France (at least) as Humoryl (not Humory as listed on the chart). I even found a French advertisement for Humoryl. :-)
http://www.geocities.com/cgkarma/home/humoryl.htmlThere is also a French data sheet for it.
http://www.biam2.org/www/Spe6410.htmlOther RIMAs on the chart had no brand names associated with them.
Posted by zeugma on August 9, 2003, at 17:47:01
In reply to Re: There's also brofaromine » SLS, posted by Ame Sans Vie on August 9, 2003, at 10:16:02
> Gee. Sounds like brofaromine should be contraindicated in people taking brofaromine, lol! I mean, with the combined MAO-A inhibition and 5-HT reuptake inhibition, wouldn't there be the same risk of serotonin syndrome as taking, say, Nardil with Zoloft? Perhaps that's why it's no longer sold?
According to an abstract i just looked at (from 1999), "Our findings indicate that BRO and MOC are as effective as tricyclic antidepressants, and they are better tolerated. However, BRO is not being studied at present, for reasons unrelated to efficacy or side effects."It's no doubt related to the perception (which the authors share) that the RIMA's are less effective than the irreversible MAOI's. But if RIMA's are 'only' as effective as TCA's, doesn't that make them MORE effective than SSRI's?
This is the end of the thread.
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