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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by freedom2001 on November 3, 2002, at 8:01:17
(R)-flextime ...The (R) -isomer of Eli Lilly's PROZAC(r) has the Potential to offer greater flexibility in treating depression compared to currently marketed antidepressants.
The unique pharmacology of (R)-fluoxetine offers the potential for more rapid onset of relief, greater efficacy for treatment of depression, and fewer side effects such as sexual dysfunction. (R)-Fluoxetine also offers the potential for treatment of additional indications, including anxiety. Improvements in its pharmacokinetic profile should allow for shorter washout and reduced drug- drug interaction. Eli Lilly has independently initiated large- scale efficacy studies with (R) - fluoxetine.In December 1998, Sepracor announced a proposed license agreement with Lilly relating to development and commercialization of (R)-fluoxetine. Under the terms of the agreement, Lilly shall have the worldwide exclusive right to develop and market products containing (R)-fluoxetine. Lilly will be responsible for all subsequent developmental work on (R)-fluoxetine, regulatory submissions, product manufacturing, marketing, and sales. Upon the effective date of the agreement, Sepracor is entitled to receive a milestone payment and license fee totaling $20 million. Sepracor also may receive up to $70 million in milestone payments based on the progression of (R)-fluoxetine through development. In addition, Sepracor is entitled to royalties on (R)-fluoxetine worldwide sales beginning upon first commercial sale. This license agreement is subject to approval by the Federal Trade Commission. PROZAC(r) (racemic fluoxetine) marketed by Eli Lilly and Company, with worldwide sales of approximately $2.6 billion in 1999, is a leading selective serotonin reuptake inhibitor for the treatment of depression
Posted by snowden on November 3, 2002, at 19:33:12
In reply to PROZAC 2, posted by freedom2001 on November 3, 2002, at 8:01:17
I'm sorry, please forgive my stupidity, but is this form of Prozac available yet? (I tried to week through the 50 cent words and medical jargon, but couldn't find an easy answer...)
Posted by freedom2001 on November 3, 2002, at 22:36:37
In reply to Re: PROZAC 2 » freedom2001, posted by snowden on November 3, 2002, at 19:33:12
> I'm sorry, please forgive my stupidity, but is this form of Prozac available yet? (I tried to week through the 50 cent words and medical jargon, but couldn't find an easy answer...)
Dear friend, I believe they are still in clinical testing phases.
Posted by Maximus on November 4, 2002, at 20:13:39
In reply to PROZAC 2, posted by freedom2001 on November 3, 2002, at 8:01:17
Posted by JLM on November 7, 2002, at 4:57:41
In reply to Re: Just another SSRI *again* (nm), posted by Maximus on November 4, 2002, at 20:13:39
This drug was abandoned by Lilly. It was found to cause cardiac QT abnormalities.
Wanna hear something interesting thou? Lilly claimed in their patent that r-fluoxetine reduces the serious side effects of Prozac that Lilly claims DO NOT EXIST. They have vehemently denied them in numerous court cases.
From the US Patent Office:
"Pure R(-) fluoxetine functions as an effective antidepressant with a shorter half life and shorter duration of action than the racemic mixture or the S(+) isomer of fluoxetine. Having a shorter half life and shorter duration of action results in less accumulation of R(-) fluoxetine in a patient's body. This in turn results in decreased adverse effects including headaches, nervousness, anxiety, insomnia, inner restlessness (akathisia), nausea, diarrhea, drowsiness, decreased libido and/or sexual dysfunction, suicidal thoughts and self mutilation."
Suicidal thoughts? Akathesia? Time and time again Lilly has denied in court that the original Prozac causes these types of adverse events, and yet they claim that their new version of the drug does NOT cause them. Does this make a damn bit of sense to anyone?
Its also HIGHLY interesting to note that one of the inventors of the drug is Martin Teicher, who wrote several papers on SSRI induced suicidality, something that Lilly has denied time and time again. In fact when he first brought it up, Lilly tried to discredit him. But later they pay 80 million for a drug that he helped developed.
My conclusion for this is that the Eli Lilly management/legal department is suffering from a severe delusional disorder and should seek treatment immediately. GRIN. But seriously, you really have to wonder. Martin Teicher's credits are IMPECABLE. So are JD Cole's, his coauthor of the suicidality studies. JD Cole I believe was once president of the American Academy of Neuropsychopharmacology.
This is the end of the thread.
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