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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Anyuser on October 9, 2002, at 11:17:15
Here is a link to a Medline abstract of an article on stereochemistry, with special emphasis on escitalopram: http://intapp.medscape.com/px/medlineapp/getdoc?ord=9&searchid=1&have_local_holdings_file=1&local_journals_only=0&searchstring=escitalopram.
The abstract states: ". . . the potential of one pure enantiomer-escitalopram, the S-enantiomer of the selective serotonin reuptake inhibitor citalopram-appears to be fulfilling its preclinical promise in the clinic."
It would be interesting to see the clinical data, but I'm not going to spend $39 to buy the article. Anybody out there have access to European Neuropsychopharmacology?
Posted by Phil on October 9, 2002, at 12:09:14
In reply to Lexapro clinical experience, posted by Anyuser on October 9, 2002, at 11:17:15
Posted by dr. dave on October 10, 2002, at 8:16:21
In reply to Lexapro clinical experience, posted by Anyuser on October 9, 2002, at 11:17:15
If you can give me the reference for the article I might be able to help - the link isn't working.
Posted by Anyuser on October 10, 2002, at 8:46:21
In reply to Re: Lexapro clinical experience » Anyuser, posted by dr. dave on October 10, 2002, at 8:16:21
Sorry about that. For some reason the link to MedLine doesn't "survive." Here's a cite: Eur Neuropsychopharmacol 2002 Oct;12(5):433 (ISSN: 0924-977X).
Posted by SLS on October 11, 2002, at 9:06:57
In reply to Lexapro clinical experience, posted by Anyuser on October 9, 2002, at 11:17:15
Hi.
Perhaps my previously-posted conjecture regarding the relative efficacies of Celexa and Lexapro warrant further exploration.
Simply put: r-citalopram might be interfering pharmacologically with the therapeutic physiological actions of s-citalopram. Perhaps this is why there is an apparent therapeutic equivalency between Celexa 60mg = Lexapro 10mg.
Why not?
Personally, I feel it is pretentious to present a posture of confidence in one's ability to exercise logic with the current dearth of information and understanding regarding the workings of the CNS held by both Psycho-Babblers and global investigative scientists alike so as to arrive at deductions to be regarded as putative phenomena.
At present, I think empirical paradigms work better than theoretical prediction as to establishing which drugs will work and not work. We're getting real close, though. Lexapro is pretty cool.
For those who complained so bitterly that Lexapro should not have been developed and approved by the FDA because, theoretically, it was simply a "me too" SSRI drug, well...
I would never want to be so smart that I should have persuaded the growing number of Lexapro responders not to bother taking it because it was nothing more than Celexa in a new package.
Could r-citalopram bind to and block the s-citalopram recognition site on the 5-HT transporter without changing allosterically the transporter molecule in such a way as to allow it to remain functional and continue to facilitate the reuptake of 5-HT? If so, r-citalopram would thus compete with, and antagonize, the therapeutic actions of s-citalopram.
IMHO - This is simply another course of logic exercised without sufficient information and understanding to be given serious consideration.
- ScottP.S. Somewhere else on the board, someone offered an absolutely brilliant suggestion. He or she proposed that a study should be conducted using only the r-citalopram enantiomer to evaluate its contribution to the evolution of side-effects (and perhaps further rate its efficacy). Absolutely cool. I wish I could remember who to credit for this idea.
This is the end of the thread.
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