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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by turalizz on June 6, 2002, at 5:21:21
Hi,
Selegiline, in the MAO-B selective dose range would increase the dopamine levels, and since dopamine is the precursor to noradrenaline, selegiline would also effect noradrenergic transmission indirectly. Am I wrong?
cem
Posted by Ritch on June 6, 2002, at 10:15:37
In reply to dopamine to noradrenaline, posted by turalizz on June 6, 2002, at 5:21:21
> Hi,
>
> Selegiline, in the MAO-B selective dose range would increase the dopamine levels, and since dopamine is the precursor to noradrenaline, selegiline would also effect noradrenergic transmission indirectly. Am I wrong?
>
> cem
Yes, it would. Perhaps a more important player is one of selegiline's metabolites-methamphetamine. That one definitely releases noradrenaline and blocks its reuptake.Mitch
Posted by Iago Camboa on June 6, 2002, at 14:09:50
In reply to Re: dopamine to noradrenaline » turalizz, posted by Ritch on June 6, 2002, at 10:15:37
> > Hi,
> >
> > Selegiline, in the MAO-B selective dose range would increase the dopamine levels, and since dopamine is the precursor to noradrenaline, selegiline would also effect noradrenergic transmission indirectly. Am I wrong?
> >
> > cem
>
> Yes, it would. Perhaps a more important player is one of selegiline's metabolites-methamphetamine. That one definitely releases noradrenaline and blocks its reuptake.
>
> MitchUnfortunately both amphetamine and methamphetamine (which are indeed selegiline's metabolites) are produced in amounts far too tiny to have ANY practical value whatsoever (either therapeutic or recreational).
Iago
Posted by jonh kimble on June 6, 2002, at 18:13:04
In reply to Re: dopamine to noradrenaline » Ritch, posted by Iago Camboa on June 6, 2002, at 14:09:50
Yes the amounts of methamphetamine are quite small and it is l- amphetamine instead of d- amphetamine. d- amphetamine is 4 times as potent. Correct me if im wrong here.
one good thing many people dont know about selegeline is that it increases tyrosine hydroxylase, which is the enzyme in your body that converts tyrosine(amino acid) into l- dopa, which is then converted into dopamine, noradrenaline and adrenaline. i guess this means more dopamine storage, and may account for some of its benefit with parkinsons.
jon
Posted by Ritch on June 6, 2002, at 23:45:36
In reply to Re: dopamine to noradrenaline » Ritch, posted by Iago Camboa on June 6, 2002, at 14:09:50
> > > Hi,
> > >
> > > Selegiline, in the MAO-B selective dose range would increase the dopamine levels, and since dopamine is the precursor to noradrenaline, selegiline would also effect noradrenergic transmission indirectly. Am I wrong?
> > >
> > > cem
> >
> > Yes, it would. Perhaps a more important player is one of selegiline's metabolites-methamphetamine. That one definitely releases noradrenaline and blocks its reuptake.
> >
> > Mitch
>
> Unfortunately both amphetamine and methamphetamine (which are indeed selegiline's metabolites) are produced in amounts far too tiny to have ANY practical value whatsoever (either therapeutic or recreational).
>
> IagoPerhaps so, depending on who is taking that medication, however it DOES show up in a urine test, BTW.
Posted by JohnX2 on June 9, 2002, at 2:51:37
In reply to Re: dopamine to noradrenaline, posted by jonh kimble on June 6, 2002, at 18:13:04
> Yes the amounts of methamphetamine are quite small and it is l- amphetamine instead of d- amphetamine. d- amphetamine is 4 times as potent. Correct me if im wrong here.
>
> one good thing many people dont know about selegeline is that it increases tyrosine hydroxylase, which is the enzyme in your body that converts tyrosine(amino acid) into l- dopa, which is then converted into dopamine, noradrenaline and adrenaline. i guess this means more dopamine storage, and may account for some of its benefit with parkinsons.
>Just my opinion...I don't buy into this for the layman, quite yet.
I've seen abstracts that suggest for non-parkinson disease treatment,
chronic administration of the MAO inhibitor selegiline , like most noradrenergic
ADs, decreases the expression of tyrosine hydroxylase..
John> jon
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