Psycho-Babble Medication Thread 107789

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Dexedrine w/ tricyclic?

Posted by Raga on May 27, 2002, at 22:59:18

I saw somewhere that taking dexedrine while being on a tricyclic will reduce the effects of the dexedrine. Is this true?
If so, to what extent is this true? Can you simply take a higher dose of dexedrine?

I'm asking because I was wondering if I could augment my 75mg of desipramine with some dexedrine (for ADD, or possibly neg. symptoms of sz - I'm also on low dose risperdal.)

Thanks for any info you can provide.
-Raga

Re: Dexedrine w/ tricyclic? » Raga

Posted by Ritch on May 27, 2002, at 23:32:01

In reply to Dexedrine w/ tricyclic?, posted by Raga on May 27, 2002, at 22:59:18

> I saw somewhere that taking dexedrine while being on a tricyclic will reduce the effects of the dexedrine. Is this true?
> If so, to what extent is this true? Can you simply take a higher dose of dexedrine?
>
> I'm asking because I was wondering if I could augment my 75mg of desipramine with some dexedrine (for ADD, or possibly neg. symptoms of sz - I'm also on low dose risperdal.)
>
> Thanks for any info you can provide.
> -Raga

Adding dexedrine should increase your desipramine blood level (due to liver enzymes that metabolize the tricyclic being inhibited by the dexedrine). It would be a good idea to get a desipramine blood level before and then after any possible dexedrine add-on, because you may need to reduce the dosage of the desipramine. I'm not sure what would happen to the *dexedrine* blood levels or what the changed "effect" of the stimulant would be if you added desipramine. I remember reading something a long time ago that desipramine had been found effective in reducing alcohol cravings by alcoholics and cocaine cravings by coke addicts. I think the researchers (in the coke study) were thinking that it would "eliminate" the high that coke would bring if a recovering coke abuser(on desipramine) relapsed and tried cocaine again. I don't know if that would be true or not. There might be somebody else here that would know.

hope this helps,

Mitch

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